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https://www.pharmamirror.com/knowledge-base/pharmaceutical-dictionary/stomach-specific-drug-delivery-system/
Nov 03, 2013 · Gastro retentive drug delivery (GRDDS) is one of the site specific drug delivery for the delivery of the drugs at stomach. It is obtained by retaining dosage form into stomach and drug is being released at controlled manner at specific site. To design a …
https://www.pharmatutor.org/articles/short-review-on-stomach-specific-drug-delivery-system
To formulate a successful stomach specific or gastroretentive drug delivery system, several techniques are currently used such as hydrodynamically balanced systems (HBS) / floating drug delivery system, 6 low density system, 7,8 raft systems incorporating alginate gels, 9,10 bioadhesive or mucoadhesive systems, 11 high density systems, 12,13 Superporous hydrogels 14 and magnetic systems. 15,16
https://www.researchgate.net/publication/258026215_Review_on_Stomach_Specific_Drug_Delivery_Systems_Development_and_Evaluation
Floating drug delivery systems have a bulk density less than gastric fluids and so, remain buoyant in the stomach for a prolonged period of time, releasing the drug slowly at the desired rate from...
https://pdfs.semanticscholar.org/857c/1072f33aaa221fb3ac056350d57dd4c3828b.pdf
Stomach Specific Floating Drug Delivery Stomach Specific FDDS have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system.
https://www.researchgate.net/publication/267856651_Stomach_specific_drug_delivery_systems_A_review
Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients Afterwards,...
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