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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398586/
2.2 Stem Cell Use in Regenerative Medicine – Potential Mechanisms of Action. The therapeutic potential of stem cells can be attributed to 3 key mechanisms of action: 1) “homing” or the process whereby systemic stem cell delivery results in cell migration to specific areas of acute injury via chemical gradients, 2) local restoration of function by differentiating into multiple cell types ...Author: Christine Tran, Margot S. Damaser
https://www.sciencedirect.com/science/article/pii/S0169409X14002154
The authors also examined the role of preconditioning stem cells prior to delivery to further enhance therapeutic potential. A subset of mice received preconditioned bone marrow stem cells that had been exposed to hypoxic conditions to upregulate several survival factors; these mice subsequently achieved the greatest functional recovery.Author: Christine Tran, Margot S. Damaser
https://hsci.harvard.edu/news/stem-cells-engineered-become-targeted-drug-factories
Stem cells engineered to become targeted drug factories September 30, 2013. A group of Brigham and Women’s Hospital, and Harvard Stem Cell Institute researchers, and collaborators at MIT and Massachusetts General Hospital have found a way to use stem cells as drug delivery vehicles. ... “If you think of a cell as a drug factory ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828437/
Apr 12, 2016 · Intrinsic resistance may be due to intratumor heterogeneity that a minor drug resistance subpopulation of cells was present in the original tumor. The cancer stem-like cell (or cancer stem cell, CSC) model provides an explanation for the phenotypic …Author: Bing Lu, Xiaojia Huang, Jingxin Mo, Wei Zhao
https://www.sciencedirect.com/science/article/pii/S0168365918307223
As a new category of cell-based targeted drug delivery system, membrane coating nanotechnology will undoubtedly have role to play. 2. Mesenchymal stem cells as a promising approach for gene or drug delivery. Initially MSCs are found at bone marrow and presented various tissues afterwards .Author: Hong-Hui Wu, Yi Zhou, Yasuhiko Tabata, Jian-Qing Gao
http://www.eurekaselect.com/111736/article
Keywords:Cancer therapy, drug delivery, mesenchymal stem cells. Abstract:Self renewal, extensive proliferation and multilineage differentiation ability in vitro and in vivo make mesenchymal stem cells (MSCs) powerful tools for tissue engineering. Beyond their potential uses in regenerative medicine, an emerging field of research aims to utilize ...
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