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https://www.sciencedirect.com/science/article/pii/S0378517317300868
The aim of this work was to develop a novel carrier-in-carrier system based on stem cell-extracellular vesicles loaded of silk/curcumin nanoparticles by endogenous technique. Silk nanoparticles were produced by desolvation method and curcumin has been selected as drug model because of its limited water solubility and poor bioavailability.Author: Sara Perteghella, Barbara Crivelli, Laura Catenacci, Milena Lillina Sorrenti, Giovanna Bruni, Vittor...
https://www.ncbi.nlm.nih.gov/books/NBK27043/
Jan 15, 2009 · This chapter will review the literature on the use of MSCs as a therapeutic drug delivery system. Mesenchymal stromal cells (MSC) are multipotent cells that can self-renew and at the same time differentiate into multiple lineages with specific surface marker expression. ... Stem cell-based therapies provide a promising approach to the treatment ...Author: Lata G Menon, Veronica J Shi, Rona S Carroll
https://www.sciencedirect.com/science/article/pii/S0168365918307223
From cell-derived peptide decorated to cell-based drug delivery systems, inspiration from the field of biology is changing the design of drug delivery systems. Cell-based targeted delivery system (TDDS) has developed as a promising delivery strategy for its low immunogenicity, intrinsic mutation rate , long circulation time, no neurotoxicity or ...Author: Hong-Hui Wu, Yi Zhou, Yasuhiko Tabata, Jian-Qing Gao
https://hsci.harvard.edu/news/stem-cells-engineered-become-targeted-drug-factories
“If you think of a cell as a drug factory, what we’re doing is targeting cell-based, drug factories to damaged or diseased tissues, where the cells can produce drugs at high enough levels to have a therapeutic effect,” said research leader Jeffrey Karp, PhD, a Harvard Stem Cell Institute principal faculty member and Associate Professor at ...
http://www.thno.org/v05p0863.htm
Cell or Cell Membrane-Based Drug Delivery Systems . Songwei Tan 1,2,3, Tingting Wu 1, Dan Zhang 1, Zhiping Zhang 1,2,3, 1. Tongji School of Pharmacy; 2. National Engineering Research Center for Nanomedicine; 3. Hubei Engineering Research Center for Novel DDS, Huazhong University of Science and Technology, Wuhan 430030, P R ChinaAuthor: Songwei Tan, Tingting Wu, Dan Zhang, Zhiping Zhang
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Other NIBIB-funded researchers are developing a system of drug delivery using a type of bacteria that has a two-part navigation system—magnetic and oxygen sensing. They have tested the delivery system in mice, achieving a remarkable success delivering drugs to tumors. The bacteria seek out oxygen-poor zones, which are a feature of tumors.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0024
Mesenchymal stem cell (MSC)‐based drug delivery strategies. The tumor tropism of MSCs can be exploited to deliver a wide variety of therapeutic agents for the treatment of cancer, such as apoptosis‐inducing agents, cytotoxic chemotherapy, anti‐angiogenic factors, immunomodulatory agents, oncolytic viruses, drug‐loaded nanoparticles ...
http://oar.a-star.edu.sg/jspui/bitstream/123456789/203/1/2012_Exosomes%20for%20drug%20delivery_a%20novel%20application%20for%20the%20mesenchymal%20stem%20cell_Biotechnology%20Advances%20review.pdf
Research review paper Exosomes for drug delivery — a novel application for the mesenchymal stem cell Ruenn Chai Lai a,1, Ronne Wee Yeh Yeo a,b,1, Kok Hian Tan c, Sai Kiang Lim a,d,⁎ a Institute of Medical Biology, A*STAR, 8A Biomedical Grove, 138648 Singapore b National University of Singapore, Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, 117456 SingaporeAuthor: Ruenn Chai Lai, Ronne Wee Yeh Yeo, Ronne Wee Yeh Yeo, Kok Hian Tan, Sai Kiang Lim
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b04697
Mesenchymal stem cell (MSC) has been increasingly applied to cancer therapy because of its tumor-tropic capability. However, short retention at target tissue and limited payload option hinder the progress of MSC-based cancer therapy. Herein, we proposed a hybrid spheroid/nanomedicine system, comprising MSC spheroid entrapping drug-loaded nanocomposite, to address these limitations. Spheroid ...Author: Smruthi Suryaprakash, Yeh-Hsing Lao, Hyeon-Yeol Cho, Mingqiang Li, Ha Yeun Ji, Dan Shao, Hanze Hu, C...
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