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https://onlinelibrary.wiley.com/doi/10.1002/9780470939956.ch27
Spinal Drug Delivery. Factors Affecting the Actions of Intrathecal Agents. Preclinical Assessment of the Toxicology of Intrathecal Agents. Some Organizing Principles for Robust Preclinical Evaluations of Spinal Drug Safety. Summary. ReferencesAuthor: Tony L. Yaksh
https://www.webmd.com/pain-management/guide/spinal-drug-delivery-systems
Pain relief through spinal drug delivery systems, also called intrathecal drug delivery systems, involves implanting a small pump or using a catheter that delivers medication directly to the spinal cord, where pain signals travel. In many cases, spinal drug delivery systems are used to treat people who have cancer pain.
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-updated-recommendations-decrease-risk-spinal-column-bleeding-and
Safety Announcement [11-6-2013] The U.S. Food and Drug Administration (FDA) is recommending that health care professionals carefully consider the timing of spinal catheter placement and removal in ...
https://journals.lww.com/neurotodayonline/Fulltext/2019/04180/Two_New_Treatments_for_Spinal_Muscular_Atrophy_May.8.aspx
An independent watchdog group said two emergent therapies for spinal muscular atrophy are not cost-effective but that does not mean neurologists should not prescribe them. The agency does not assess what the drug is worth for an individual patient or family; it considers the cost-effectiveness of drugs from a societal perspective.
https://neuromodulation.org/Portals/0/For%20Patients%20Education%20Page/Spinal%20Drug%20Delivery%20Systems.pdf
Spinal Drug Delivery Systems. A spinal drug delivery system infuses medicines directly into the spinal fluid and to the spinal cord. Cells that have a big influence on the perception of pain are located in the spinal cord, and this direct delivery can have a very potent and profound pain-relieving effect.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-spinal-muscular-atrophy
December 23, 2016. The U.S. Food and Drug Administration today approved Spinraza (nusinersen), the first drug approved to treat children and adults with spinal muscular atrophy (SMA), a rare and often fatal genetic disease affecting muscle strength and movement.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703007/
Efficacy and safety of transdermal buprenorphine has been well established in chronic pain but data regarding acute post-operative pain relief in spinal surgery are still very limited. The aim of this study was to evaluate the analgesic efficacy of transdermal buprenorphine patch for postoperative pain relief in patients undergoing spinal instrumentation surgery.Author: Saikat Niyogi, Pratibha Bhunia, Jisnu Nayak, Sankari Santra, Amita Acharjee, Indrani Chakraborty
https://academic.oup.com/bja/article/93/4/568/304476
Jun 25, 2004 · Assessment of intrathecal drug spread Studies of drug distribution usually involve measurements of concentration in a relevant body fluid compartment over time. However, multiple sampling of CSF at one level, let alone at the several needed to build an image of drug distribution through the theca, is not practical and would significantly influence the observations anyway.Author: G. Hocking, J.A.W. Wildsmith
https://journals.lww.com/nursing/Fulltext/2012/08000/Epidural_analgesia__What_nurses_need_to_know.15.aspx
Previous back surgery (such as spinal fusion) Important safety considerations. Be sure to keep your patients safe while they're receiving epidural analgesia. Errors in medication delivery pose the most significant risk of epidural analgesia.
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