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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313811
Adeno-associated virus (AAV) is widely used as a gene transfer vector in biomedical and gene therapy studies. 5 AAV serotype 9 (AAV9) can efficiently transduce cardiac myocytes, among other cell and tissue types. 6 AAV9 can package sequences up to 4.7 kb that may include a tissue-specific promoter that drives gene expression in the transduced cells. 7 Atrial-specific gene delivery could, therefore, …Author: Li Ni, Larry Scott, Hannah M Campbell, Xiaolu Pan, Katherina M Alsina, Julia O Reynolds, Leonne E Ph...
https://www.ncbi.nlm.nih.gov/pubmed/30582449
Jan 18, 2019 · Atrial natriuretic factor (ANF) promoter drives gene expression specifically in atrial cardiomyocytes. OBJECTIVE: To establish the platform of atrial specific in vivo gene delivery by AAV-ANF. METHODS AND RESULTS: We constructed AAV vectors based on serotype 9 (AAV9) that are driven by the atrial-specific ANF promoter.Author: Li Ni, Larry Scott, Hannah M Campbell, Xiaolu Pan, Katherina M Alsina, Julia O Reynolds, Leonne E Ph...
https://www.ncbi.nlm.nih.gov/pubmed/24035974
Dec 28, 2013 · Non-specific delivery to these organs must be overcome if tumors are to be aggressively treated with genes such as IL-12 which activates a tumor immune response, and TNF-alpha which can induce tumor cell apoptosis.Author: Max Kullberg, Ryan McCarthy, Thomas J. Anchordoquy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659361/
The 2-source magnetic targeting strategy employed here for site-specific gene delivery to stented arteries is another important determinant of the effectiveness of the present experimental approach. The inability to target nonsuperficially located sites in humans using a single magnet as the field source remains one of the principal limitations to the clinical applicability of magnetic targeting strategies ( 40 ).Author: Michael Chorny, Ilia Fishbein, Jillian E. Tengood, Richard F. Adamo, Ivan S. Alferiev, Robert J. Lev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608830/
The ideal vector for gene transfer should result in high tissue-specific transgene expression with minimal off-target gene delivery. Tissue or cell-specific promoters reduce off-target gene expression and studies have identified both CyP19a and PLAC1 as genes with trophoblast-specific promoters [ 17 , 18 ].Author: Noura Abd Ellah, Noura Abd Ellah, Leeanne Taylor, Weston Troja, Kathryn Owens, Neil Ayres, Giovanni ...
https://www.nature.com/articles/gt2010105
Aug 12, 2010 · The newly isolated AAV serotypes (AAV-1, -6, -8 and -9) have been shown to deliver genes efficiently to various organs including skeletal muscle, …Author: Konkal-Matt R. Prasad, Yaqin Xu, Zequan Yang, Scott T. Acton, Brent A French
https://www.nature.com/articles/s41598-019-38533-7
Feb 07, 2019 · This significantly increased the ratio of specific IgG and IgA to HIV env in fecal extracts and sera, suggesting that HEV-VLPs could be used as tools for the delivery of foreign genes 21.Author: Eun Byul Lee, Jung-Hee Kim, Wonhee Hur, Jung Eun Choi, Sung Min Kim, Dong Jun Park, Byung-Yoon Kang,...
https://www.pnas.org/content/96/21/11696
The liver poses formidable obstacles to hepatocyte-specific gene delivery. Many liposomes that effectively deliver genes to other cell types do not efficiently target the hepatocyte, often winding up instead in the Kupffer cell, a hepatic macrophage.
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