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https://onlinelibrary.wiley.com/doi/10.1002/9781118444726.ch4
The chapter on solid lipid nanoparticles introduces colloidal suspensions of crystalline lipids as carrier systems for poorly water‐soluble drugs. It describes and compares the various methods to prepare these carrier systems, in particular, different melt‐dispersion and precipitation techniques.Author: Sonja Joseph, Heike Bunjes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865805/
In effect, the drug containing solid lipid is pulverized to micropaticles by ball/mortar milling. Typical particle sizes attained are in the range 50-100 microns. Chilled processing further facilitated particle milling by increasing the lipid fragility. The SLNs are dispersed in a chilled emulsifier solution.
https://www.sciencedirect.com/science/article/pii/S0939641100000874
The lipid nanopellets for oral delivery developed by Speiser are produced by dispersing a melted lipid in a surfactant solution by stirring or sonication. The obtained particle size is determined by the power density of the stirrer. In general, a mixture of nanoparticles and microparticles is obtained [36], [46].Author: Rainer H. Müller, Karsten Mäder, Sven Gohla
http://www.icpjonline.com/documents/Vol1Issue11/08.pdf
Nanoparticles are solid colloidal particles ranging from 10 to 1000 nm û1.0 μmü, in which the active principles (drug or biologically active material) are dissolved, entrapped, and/or to which the active principle is adsorbed or attached (Chow- dary et al., 1997).
http://www.authorstream.com/Presentation/chatap-1304263-solid-lipid-nanoparticles-by/
Jan 14, 2012 · Solvent emulsification/ evaporation : Lipophilic material is dissolved in a water immiscible organic solvent ( e.g.cyclohexane ) that is emulsified in an aqueous phase. Upon evaporation of solvent, a nanoparticle dispersion is formed by precipitation of lipid in aq.
https://www.sciencedirect.com/science/article/pii/S0939641197001501
Nanoparticles made from solid lipids are attracting increasing attention as colloidal drug carriers for i.v. application 1, 2, 3. The nanoparticles are in the submicron size range (50–1000 nm) and they are composed of physiological lipids. At room temperature the particles are in the solid state.Author: Annette zur Mühlen, Cora Schwarz, Wolfgang Mehnert
http://www.authorstream.com/Presentation/amolamrutkar11-1373225-solid-lipid-nanoparticles-amol/
Mar 28, 2012 · Solid lipid nanoparticles The solid lipid nanoparticles (SLN’s) are submicron colloidal carriers which are composed of physiological lipid, dispersed in water or in an aqueous surfactant solution. They consist of macromolecular materials in which the active principle ( drug or biologically active material ) is dissolved, entrapped, and or to ...
https://www.slideshare.net/NIVETASINGH/solid-lipid-nanoparticles-74709943
Apr 08, 2017 · CONTENTS 1. Introduction Definition of Solid lipid Nanoparticles Significance of Lipid Based systems Types of Solid lipid Nanoparticles Method of Preparation of SLNs Characterization of SLN Principle of drug release from SLNs Advantages and Disadvantages Applications of SLNs 3.
https://www.slideshare.net/anay_ict/solid-lipid-nanoparticles
Mar 25, 2012 · NLC are lipid particles with a controlled nanostructure thatimproves drug loading and firmly incorporates the drug duringstorage .Owing to their properties and advantages, SLN and NLC may findextensive application in topical drug delivery, oral and parentaladministration of cosmetic and pharmaceutical actives.Cosmeceuticals is emerging as the biggest application target of
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