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https://www.sciencedirect.com/science/article/pii/S0928098703001647
Medical applications of genetically engineered polymers are on the horizon, including: depots for drug delivery, hydrogels for pulsatile drug delivery, improved targeted delivery, two stage drug delivery systems, sutures, wound coatings, artificial tendons, tissue engineering, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants for repair of spinal discs, …Author: Jindřich Kopeček
https://www.sciencedirect.com/science/article/abs/pii/S0928098703001647
The design, synthesis, and properties of novel stimuli-sensitive and genetically engineered biomaterials and drug delivery systems are reviewed. Two approaches to their engineering are presented. One approach is to improve the traditional methods of synthesis, as demonstrated by the example of controlled copolymerization of α-amino acid N -carboxyanhydrides.Author: Jindřich Kopeček
https://www.ncbi.nlm.nih.gov/pubmed/13678788
The design, synthesis, and properties of novel stimuli-sensitive and genetically engineered biomaterials and drug delivery systems are reviewed. Two approaches to their engineering are presented. One approach is to improve the traditional methods of synthesis, as demonstrated by the example of controlled copolymerization of alpha-amino acid N-carboxyanhydrides.Author: Jindřich Kopeček
https://www.researchgate.net/publication/257380556_Smart_and_genetically_engineered_biomaterials_and_drug_delivery_systems
Novels drug delivery systems composed of smart peptides and molecules have the ability to drive self-assembly and form hydrogels at physiological pH.Author: Jindřich Kopeček
https://www.sciencedirect.com/book/9780081017500/engineering-of-biomaterials-for-drug-delivery-systems
Development of biomaterials toward drug delivery applications is an active area of research. Drug delivery systems are often PEGylated (modification using polyethylene glycols or PEG) in order to introduce biocompatibility and bypass the immune system responses.
https://www.elsevier.com/books/engineering-of-biomaterials-for-drug-delivery-systems/parambath/978-0-08-101750-0
Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its …
https://www.sciencedirect.com/science/article/pii/S0142961207005625
Biological applications of this technology currently under development span diverse areas including bioseparation, drug delivery, reusable enzymatic catalysts, molecular switches, biosensors, regulated protein folding, microfluidics, and gene therapy. Smart polymers may offer promise for revolutionary improvements in TE scaffolds.Author: Mark E. Furth, Anthony Atala, Mark E. Van Dyke
https://www.researchgate.net/publication/318293455_THE_NOVEL_DRUG_DELIVERY_SYSTEM
Oral controlled drug delivery forms a crucial facet among novel drug delivery systems. Rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamic profile of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212614/
One of the domains, the coiled-coil, ubiquitously found in nature, has been used as an example to demonstrate the developments in the design of smart hydrogels. The application potential of synthetic, protein-based, DNA-based, and hybrid hydrogels bodes well for the future of this class of biomaterials.Author: Jindřich Kopeček
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Ideally, future health care will incorporate smart delivery systems that can bypass cellular defenses, transport drugs to targeted intracellular sites, and release the drugs in response to specific molecular signals. Combining Diagnosis and Treatment Reviewed October 2016
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