We have collected information about Site Specific Drug Delivery To Colon for you. Follow the links to find out details on Site Specific Drug Delivery To Colon.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · The polymers described as pH dependent in colon specific drug delivery are insoluble at low pH levels but become increasingly soluble as pH rises.21 Although a pH dependent polymer can protect a formulation in the stomach, and proximal small intestine, it may start to dissolve in the lower small intestine, and the site-specificity of formulations can be poor.22 The decline in pH from the end …Author: Anil K. Philip, Betty Philip
https://www.japsonline.com/admin/php/uploads/363_pdf.pdf
The colon is a site where both local and systemic delivery of drugs can take place. To achieve successful colon targeted drug delivery, a drug need to be protected from degradation, release and absorption in the upper portion of the gastric
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
http://ijpsr.com/bft-article/a-review-on-colon-targeted-drug-delivery-system/?view=fulltext
Site-specific delivery into the colon is not only needed for local treatment of a variety of colon diseases, like ulcerative colitis, Chron’s diseases, amoebiasis, colon cancer, but also systemic delivery of proteins and peptides this is because of less diversity and intensity of digestive enzymes and less proteolytic activity of colon mucosa than that observed in the small intestine.
https://www.sciencedirect.com/science/article/pii/S0378517310003467
Aug 16, 2010 · Furthermore, the design of controlled release systems for optimal drug delivery to the proximal colon requires a detailed knowledge of the relationship between particle size, colonic dispersion and colonic transit rates and of the factors which influence colonic transit rates and consequent drug bioavailability (Barrow et al., 1991).Author: João F. Pinto
https://sites.ualberta.ca/~csps/JPPS6(1)/S.Chourasia/colon.htm
A capsule consisting of EC was prepared and evaluated for site-specific drug delivery to the colon (207). It is composed of a low substituted hydroxy propyl cellulose drug container, a capsule body and a capsule made of EC.
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · Azo polymeric new drug In which use of polymers as drug carriers for drug delivery to colon . Synthetic, naturally, sub-synthetic polymers used form colon targeted polymeric prodrug with azo linkage between polymer & drug moiety. The various azo polymers are evaluated for coating materials over drug core.
https://pdfs.semanticscholar.org/f4b6/80ebcdefab271ed61e5bbca722a3da0760c5.pdf
The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. In the recent times, the colon specific drug delivery system is also gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein & peptide drugs.
Searching for Site Specific Drug Delivery To Colon?
You can just click the links above. The data is collected for you.
