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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo . siRNA duplexes can be monobiotinylated , which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin ...Author: William M. Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
The study demonstrates the efficacy of CPP conjugated siRNA duplexes in targeting primary neurons in vitro and the CNS tissue in vivo (however, this is via invasive administration of the siRNA directly to the brain tissue by convection enhanced delivery). The approach has minimal toxicity towards the targeted cells, in contrast to reported ...Author: Saroj P Mathupala
https://www.sciencedirect.com/science/article/pii/S0168365914008396
Nanotechnology offers a new platform for therapeutic delivery of antiretrovirals to the central nervous system (CNS). Nanoformulated antiretroviral drugs offer multifunctionality, that is, the ability to package multiple diagnostic and therapeutic agents in the same nanocompose, along with the added provisions of site-directed delivery, delivery across the blood–brain-barrier (BBB), and ...Author: Mª Jesús Serramía, Mª Jesús Serramía, Susana Álvarez, Susana Álvarez, Elena Fuentes-Paniagua, Maria ...
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Finally, we outline how to use exosomes to efficiently deliver siRNA in vitro and in vivo in mouse brain. Examples of anticipated results in which exosome-mediated siRNA delivery is evaluated by ...Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.researchgate.net/post/What_is_the_best_way_of_delivering_siRNA_in_vivo
What is the best way of delivering siRNA in vivo? ... but even then delivery to organs like the brain is far less efficient than say the kidney. Regardless, in vivo gene silencing is an ...
https://www.researchgate.net/publication/270654258_In_vivo_delivery_of_siRNA_to_the_brain_by_carbosilane_dendrimer
In vivo delivery of siRNA to the brain by carbosilane dendrimer. ... Apart from the aforementioned dendrimers, carbosilane dendrimers have also been applied for in vivo siRNA delivery to the brain.
https://www.sciencedirect.com/science/article/pii/S0169409X07000221
The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Fig. 6, Fig. 7 demonstrate the delivery of PNA antisense agents to brain in vivo . siRNA duplexes can be monobiotinylated , which allows for high efficiency attachment to molecular Trojan horses using avidin–biotin ...Author: William M. Pardridge
https://www.liebertpub.com/doi/full/10.1089/hum.2010.083
However, delivery of siRNA to the brain has not been well established. For in vivo delivery of siRNA, viral vectors and high-pressure, high-volume intravenous injection methods have been described. However, these approaches have limitations in clinical practice due to their side effects.Author: Yoshitaka Uno, Wenying Piao, Kanjiro Miyata, Kazutaka Nishina, Hidehiro Mizusawa, Takanori Yokota
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