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https://www.sciencedirect.com/science/article/pii/S1818087614000646
Still, the exact endosomal release mechanism of many siRNA delivery systems is poorly understood. Additionally, low toxicity is the most important part of siRNA delivery systems. If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless.Author: Cong-fei Xu, Jun Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877448/
Sep 15, 2015 · Gene silencing mechanisms of siRNA and miRNA. siRNA: dsRNA (either transcribed or artificially introduced) is processed by Dicer into siRNA which is loaded into the RISC. AGO2, which is a component of RISC, cleaves the passenger strand of siRNA. The guide strand then guides the active RISC to the target mRNA.Author: Jenny K W Lam, Jenny K W Lam, Michael Y T Chow, Yu Zhang, Susan W S Leung, Susan W S Leung
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30023-4
Jun 01, 2018 · Gene Delivery of siRNA-IRF5 with MG1 Homing Peptides Targeting Microglia in Neuropathic Pain Mice. Gene therapy was performed for neuropathic pain by the knockdown of IRF5 using the MG1 peptide+siRNA-IRF5 complex (peptides, 3 μg; siRNA, 1 μg) and the comparative groups, which were MG2, AS1, and DRG complexes ...Author: Tomoya Terashima, Nobuhiro Ogawa, Yuki Nakae, Toshiyuki Sato, Miwako Katagi, Junko Okano, Hiroshi Ma...
https://www.sciencedirect.com/science/article/pii/S0168365919306108
They investigated the gene delivery potential (both pDNA and siRNA) of a range of well-defined starshaped L-lysine polymers with varying number of peptide arms, including linear, 8–, 16–, 32– and 64–arm polymers. They reported that star-shaped poly(l-lysine) was much more efficient at condensing pDNA and siRNA than linear poly(l-lysine).Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125806/
Small interfering RNA (siRNA) delivery is a prospective method in gene therapy, but it has application limitations such as negative charge, water solubility and high molecular weight. In this study, a safe and efficient nano-vector, CRS, was designed and synthesized to facilitate siRNA delivery.Author: Wen Zhao, Yifan Zhang, Xueyun Jiang, Chunying Cui
https://www.nature.com/articles/3302688
Jan 05, 2006 · Importantly, peptide based siRNA delivery systems have also been shown to be important in the nuclear delivery of siRNAs designed to specifically target …Author: K V Morris, J J Rossi
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · Therapeutics based on small interfering RNA (siRNA), which in principle are able to reversibly silence any gene of interest, are under development for the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://pubs.acs.org/doi/10.1021/bc800278e
Nov 17, 2008 · Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy. Drug Delivery and Translational Research 2017, 7 (2) , 346-358. DOI: 10.1007/s13346-016-0352-5. Jie Chen, Xiuwen Guan, Yingying Hu, Huayu Tian, Xuesi Chen. Peptide-Based and Polypeptide-Based Gene Delivery Systems.Author: Ji Hoon Jeong, Hyejung Mok, Yu-Kyoung Oh, Tae Gwan Park
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/enhanced-sirna-delivery-and-long-term-gene-silencing.html
Figure 1. Gene Silencing After Retroviral Delivery of siRNA. Retroviral vectors expressing the indicated siRNA inserts from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following infection, virus was collected and used to infect HeLa cells in triplicate.
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