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https://www.sciencedirect.com/science/article/pii/S016836591001000X
The cationic siRNA–PLGA/LPEI micelles showed superior intracellular uptake and enhanced gene silencing effect, compared to naked siRNA/LPEI complexes. The hybrid micelle structure based on siRNA and PLGA can be potentially used as an efficient siRNA delivery system for gene silencing.Author: Soo Hyeon Lee, Hyejung Mok, Yuhan Lee, Tae Gwan Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204797/
Additionally, PLGA nanoparticles can be modified for targeted delivery [15,16]. The major drawback of PLGA nanoparticles is low siRNA delivery efficiency, although new strategies for improvement by enhancing cell uptake [ 17 - 21 ], increasing endosomal escape [ 21 , 22 ], increasing nucleus translocation [ 23 , 24 ] and enhancing RNAi potency ...Author: Jiangbing Zhou, Toral R. Patel, Michael Fu, James P. Bertram, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418083/
Aug 03, 2012 · By detecting Cy5 fluorescence (excitation 649 nm/emission 670 nm), the delivery efficacy of Cy5 siRNA by PLGA NPs was determined by comparing the amount of Cy5 siRNA in the supernatant with the initial amount of Cy5 siRNA. The drug loading of PLGA-PEI-TAX and PLGA-PEI-Cy5-S3SI was 2.43% and 32.1%, respectively.
https://www.nature.com/articles/s41598-018-25930-7
May 14, 2018 · Therefore, PLGA nanoparticles for delivering siRNA oligo have attracted great interests as an alternative delivery system to the commonly used polycationic delivery systems that …Author: Chitra Risnayanti, Chitra Risnayanti, Yeong-Su Jang, Jinju Lee, Hyung Jun Ahn
https://www.nature.com/articles/s41598-019-52142-4
Nov 01, 2019 · Short interfering RNA (siRNA) possesses special ability of silencing specific gene. To increase siRNA stability, transportation and its uptake by tumor cells, effective delivery to …Author: Azmat Ali Khan, Amer M. Alanazi, Mumtaz Jabeen, Arun Chauhan, Mohammad Azam Ansari
https://www.sciencedirect.com/science/article/pii/S0939641110002973
Poly(dl-lactide-co-glycolide acid) (PLGA) is an attractive polymer for delivery of biopharmaceuticals owing to its biocompatibility, biodegradability and outstanding controlled release characteristics.The purpose of this study was to understand and define optimal parameters for preparation of small interfering RNA (siRNA)-loaded PLGA nanoparticles by the double emulsion solvent evaporation ...Author: Dongmei Cun, Ditte Krohn Jensen, Morten Jonas Maltesen, Matthew Bunker, Paul Whiteside, David Scurr,...
https://pubs.acs.org/doi/10.1021/nn300106t
Composite nanofibers of biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Author: Menglin Chen, Shan Gao, Mingdong Dong, Jie Song, Chuanxu Yang, Kenneth Alan Howard, Jørgen Kjems, Fl...
https://www.mdpi.com/1422-0067/13/1/516/pdf
mPEG-PLGA-PLL triblock copolymers can be potentially applied as novel non-viral vectors for improving siRNA delivery and gene silencing. Keywords: gene silencing; nanoparticles; PLGA; PLL; siRNA delivery; GFP 1. Introduction Small interfering RNA (siRNA) is a promising biological strategy for treatment of diverse diseases,Author: Jing Du, Ying Sun, Qiu-Sheng Shi, Pei-Feng Liu, Ming-Jie Zhu, Chun-Hui Wang, Lian-Fang Du, You-Rong ...
https://www.researchgate.net/publication/23402893_Polymeric_Nanoparticles_for_siRNA_Delivery_and_Gene_Silencing
The unique characteristics that make PLGA-based NPs promising candidates for siRNA delivery include their ability to protect the siRNA molecules from degradation, overcoming the cell membrane ...
https://pubs.acs.org/doi/10.1021/nl2035354
The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32–46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.Author: Warefta Hasan, Kevin Chu, Anuradha Gullapalli, Stuart S. Dunn, Elizabeth M. Enlow, J. Christopher Lu...
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