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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179298/
Sep 28, 2014 · 4. Brain drug delivery. A significant amount of work in single compartment drug delivery to the brain has focused on brain cancer treatments. Brain cancer treatments aim to bypass the blood-brain barrier (BBB) altogether. A local delivery approach ensures that the central nervous system (CNS) is exposed to the majority of the dose.Author: Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spen...
https://www.sciencedirect.com/science/article/pii/S016836591400282X
4. Brain drug delivery. A significant amount of work in single compartment drug delivery to the brain has focused on brain cancer treatments. Brain cancer treatments aim to bypass the blood–brain barrier (BBB) altogether. A local delivery approach ensures that the central nervous system (CNS) is exposed to the majority of the dose.Author: Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spen...
https://www.sciencedirect.com/science/article/abs/pii/S016836591400282X
We discuss the rationale behind single compartment drug delivery for each of these compartments, and give an overview of examples at different development stages, from the lab bench to phase III clinical trials to clinical practice. We approach single compartment drug delivery from both a translational and a technological perspective.Author: Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spen...
https://www.researchgate.net/publication/262075636_Single_compartment_drug_delivery
Single compartment drug delivery. Drug design is built on the concept that key molecular targets of disease are isolated in the diseased tissue. Systemic drug administration would be sufficient for targeting in such a case.
http://dspace.mit.edu/handle/1721.1/101146
This review focuses on drug delivery methods that physically target drugs to individual compartments of the body. Compartments such as the bladder, peritoneum, brain, eye and skin are often sites of disease and can sometimes be viewed as “privileged,” since they intrinsically hinder partitioning of systemically administered agents.
https://core.ac.uk/display/78067832
Additionally, systemic administration may not lead to local drug concentrations high enough to yield disease modification because of rapid systemic metabolism or lack of sufficient partitioning into the diseased tissue compartment. This review focuses on drug delivery methods that physically target drugs to individual compartments of the body.Author: Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spen...
http://europepmc.org/abstract/MED/24798478
Oct 01, 2014 · We discuss the rationale behind single compartment drug delivery for each of these compartments, and give an overview of examples at different development stages, from the lab bench to phase III clinical trials to clinical practice. We approach single compartment drug delivery from both a translational and a technological perspective.Author: Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spen...
https://sepia.unil.ch/pharmacology/index.php?id=72
In single-compartment modeling, the drug is considered to be distributed instantaneously into a unique compartment in the body. This compartment is characterized by a distribution volume. The drug input into this volume depends on the dosage regimen. The drug output from this volume is characterized by an elimination constant rate.
https://www.westpharma.com/products/self-injection-platforms/smartdose?%20English
The SmartDose platform offers a wearable, subcutaneous injector with an integrated drug delivery system that incorporates human factors and usability testing to deliver a truly patient-centric approach to self-administration.
https://chemistrycommunity.nature.com/users/345661-idil-cazimoglu/posts/58516-controlled-release
Feb 18, 2020 · Aqueous compartments bound by lipid membranes are increasingly used in drug delivery. The majority of these structures currently used in medicine are single compartment liposomes that release their contents slowly over a pre-determined length of time or suddenly upon a trigger such as temperature [1,2,3].
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