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https://www.researchgate.net/publication/11867563_Simulation_of_the_Delivery_of_Doxorubicin_to_Hepatoma
A twodimensional (2D) model, in which the delivery of doxorubicin to a hepatoma segmented of a patient CT-scan was simulated, included the extracellular binding and DNA binding of the drug (Goh et ...
https://link.springer.com/10.1023/A:1011076110317
Purpose. To develop a two-dimensional simulation platform for the transport of doxorubicin to the hepatoma. To examine the temporal and spatial variation of doxorubicin concentration and its penetration into the tumor and the surrounding normal tissues. Methods. Simulations are carried out with Fluent/UNS using the finite volume method to obtain the interstitial fluid pressure, velocity, and ...Author: Yin-Min Felicia Goh, Hwai Loong Kong, Chi-Hwa Wang
https://www.ncbi.nlm.nih.gov/pubmed/11474779
Simulation of the delivery of doxorubicin to hepatoma. Goh YM(1), Kong HL, Wang CH. Author information: (1)Department of Chemical and Environmental Engineering National University of Singapore. PURPOSE: To develop a two-dimensional simulation platform …Author: Yin-Min Felicia Goh, Hwai Loong Kong, Chi-Hwa Wang
https://iopscience.iop.org/article/10.1088/0031-9155/59/20/5987/pdf
Several simulation studies in the past had extensively investigated the delivery of free, stealth and thermosensitive Dox to a peripheral tumor site (El-Kareh and Secomb 2000, Goh et al2001, El-Kareh and Secomb 2005, Eikenberry 2009, Zhan and Xu 2013). However, these existing models address the transport of Dox to the hepatoma ratherAuthor: Tam Nhan, Tam Nhan, Alison Burgess, Lothar Lilge, Lothar Lilge, Kullervo Hynynen, Kullervo Hynynen
https://core.ac.uk/display/48758775
Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): http://scholarbank.nus.edu.sg/... (external link)Author: Y.-M.F. Goh, H.L. Kong and C.-H. Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315397/
Feb 17, 2017 · Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes.Author: Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu
https://www.hindawi.com/journals/jdd/2013/172529/
The effectiveness of anticancer treatments is often hampered by the serious side effects owing to toxicity of anticancer drugs and their undesirable uptake by healthy cells in vivo . Thermosensitive liposome-mediated drug delivery has been developed as part of research efforts aimed at improving therapeutic efficacy while reducing the associated side effect.Author: Wenbo Zhan, Xiao Yun Xu
https://clincancerres.aacrjournals.org/content/12/8/2563
Apr 15, 2006 · Background: In the fight against cancer, new drug delivery systems are attractive to improve drug targeting of tumors, maximize drug potency, and minimize systemic toxicity. We studied a new drug delivery system comprising microspheres, with unique properties allowing delivery of large amounts of drugs to tumors for a prolonged time, thereby decreasing plasma levels. Liver tumors, …Author: Kelvin Hong, Afsheen Khwaja, Eleni A Liapi, Michael S. Torbenson, Christos S Georgiades, Jean Franco...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172276
Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficacy for each tumour is evaluated by using a ...Author: Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu
https://iopscience.iop.org/article/10.1088/0031-9155/59/20/5987/meta
Sep 17, 2014 · Doxorubicin (Dox) is a well-established chemotherapeutic agent, however it has limited efficacy in treating brain malignancies due to the presence of the blood-brain barrier (BBB). Recent preclinical studies have demonstrated that focused ultrasound induced BBB disruption (BBBD) enables efficient delivery of Dox to the brain.Author: Tam Nhan, Tam Nhan, Alison Burgess, Lothar Lilge, Lothar Lilge, Kullervo Hynynen, Kullervo Hynynen
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