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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.200400771
Nov 30, 2004 · To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system.Author: Christophe Barbé, John R Bartlett, Linggen Kong, Kim S Finnie, Hui Qiang Lin, Michael Larkin, Sandri...
https://www.researchgate.net/publication/237080478_Silica_Particles_A_Novel_Drug-Delivery_System
In contrast, silica particles offer a biocompatible, stable, and "stealthy" alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol-gel polymerization with either spray-drying or emulsion chemistry. Spray-drying faces challenges, including low yield,...
https://www.academia.edu/6406591/Silica_Particles_A_Novel_Drug-Delivery_System
(PDF) Silica Particles: A Novel Drug-Delivery System Alexandra Bush - Academia.edu In recent decades, significant advances in drug-delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been
https://www.sciencedirect.com/science/article/pii/B9780128136614000018
Silica-based nanoparticles are used as excipients in pharmaceutical technology. Recently, mesoporous silica nanoparticles have emerged as drug delivery systems. Their porous structure enables the high drug-loading of drugs with poor water solubility. The silica matrix protects entrapped drugs against enzymatic degradation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522861/
Drug delivery. Porous silica based materials for drug delivery applications emerged in the late 1990's with reports of silica nanopore membranes; one major advantage of the PSi materials is that they can be tailored for continuous or triggered drug release depending on the application. The paracellular delivery of insulin across an intestinal Caco-2 cell monolayer using micro fabricated PSi particles was one of the first examples of drug delivery …
https://www.sciencedirect.com/science/article/pii/S1549963414005462
From the Clinical Editor. This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems.Author: Ying Wang, Qinfu Zhao, Ning Han, Ling Bai, Jia Li, Jia Liu, Erxi Che, Liang Hu, Qiang Zhang, Tongyin...
https://www.researchgate.net/publication/307612254_NANOPARTICLES_AS_A_NOVEL_DRUG_DELIVERY_SYSTEM_A_REVIEW
Novel drug delivery systems attempt to work either by controlled release, or by maintaining a relatively constant, effective drug level in the body with concomitant minimization of unwanted side ...
https://www.mdpi.com/2073-4360/12/4/888/htm
Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers by Andrzej Baliś , Karol Wolski and Szczepan Zapotoczny * Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland
http://ijpsr.com/bft-article/novel-drug-delivery-systems-an-overview/?view=fulltext
In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. An appropriately designed Novel Drug Delivery System can be a major advance for solving the problems related towards the release of the drug at specific site with specific rate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519006/
Dec 05, 2012 · The constructed silica-coated liposomes, called “Liposil,” possessed the high stability of silica materials and versatile drug-loading capabilities of liposomes, providing a novel potential carrier for drug delivery, especially in hostile bioenvironments.Author: Chong Li, Yan Zhang, Tingting Su, Lianlian Feng, Yingying Long, Zhangbao Chen
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