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https://www.hopkinsmedicine.org/health/conditions-and-diseases/sickle-cell-disease
Sickle cell disease is a blood disorder in which the hemoglobin is damaged and can't carry oxygen to the tissues. These blood cells with the defective hemoglobin are sticky and can build up and block small blood vessels leading to pain and other complications of the disease.
https://www.practicalpainmanagement.com/pain/other/sickle-cell-pain-crisis-clinical-guidelines-use-oxygen
Defining Sickle Cell Disease and Its Economic Burden. Sickle cell disease (SCD) is the consequence of homozygosity for a single amino acid change in the β-globin chain that results in structurally abnormal hemoglobin S, or by compound heterozygosity for hemoglobin S and another β-globin chain abnormality, typically hemoglobin C or β-thalassemia.
https://www.ncbi.nlm.nih.gov/pubmed/19126993
Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS). Bowers AS(1), Pepple DJ, Reid HL. Author information: (1)Department of Basic Medical Sciences, Physiology Section, Faculty of Medical Sciences, University of the West Indies, Jamaica, West Indies.Author: A.S. Bowers, D.J. Pepple, H.L. Reid
https://sicklecellanemianews.com/2019/03/05/brain-oxygen-supply-silent-strokes-sickle-cell-patients/
Mar 05, 2019 · Brain oxygen supply is different in different regions of the brain of sickle cell disease (SCD) patients who are affected by anemia, which may explain the incidence of silent strokes, a recent study says.. The findings of the study, “White matter has impaired resting oxygen delivery in sickle cell patients,” were published in the American Journal of Hematology.1/5(1)
https://sicklecellanemianews.com/what-is-sickle-cell-anemia/
Sickle cell anemia is an inherited disease that affects red blood cells with an abnormal version of hemoglobin, the protein that carries oxygen throughout the body. The altered hemoglobin is known as hemoglobin S, or sickle hemoglobin, because it causes normally oval-shaped red blood cells to...
https://www.ncbi.nlm.nih.gov/pubmed/30697803
White matter has impaired resting oxygen delivery in sickle cell patients. ... There was spatial co-localization between regions of low oxygen delivery and WM hyperintensities on T2 FLAIR imaging. To conclude, oxygen delivery is preserved in the GM of SCD patients, but is decreased throughout the WM, particularly in areas prone to WM silent ...Author: Yaqiong Chai, Adam M. Bush, Julie Coloigner, Aart J. Nederveen, Benita Tamrazi, Chau Vu, Soyoung Cho...
https://www.nhlbi.nih.gov/health-topics/sickle-cell-disease
Sickle cell disease is an inherited disease caused by defects, called mutations, in the beta globin gene that helps make hemoglobin.Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it through the arteries to all the cells in the tissues of the body.
https://www.bmc.org/healthcity/population-health/covid-19-sickle-cell-disease-and-critical-need
Mar 25, 2020 · Sickle cell disease is an inherited disorder causing normal red blood cells to deform into stiff, crescent shapes that get stuck in small blood vessels blocking blood flow and oxygen delivery to many parts of the body. This ‘sickling’ is triggered by events such as viral illnesses, cold weather, stress, and low oxygen, among others.
https://www.news-medical.net/news/20190207/Researcher-studies-how-sickle-cell-disease-affects-blood-flow-and-oxygen-delivery.aspx
Feb 07, 2019 · Sickle Cell Disease is rare but devastating. Due to a genetic mutation affecting hemoglobin, the component of the red blood cell that carries oxygen, a reduced amount of oxygen …
https://www.drugs.com/cg/sickle-cell-crisis-inpatient-care.html
Feb 03, 2020 · A sickle cell crisis is a painful episode that occurs in people who have sickle cell anemia. It happens when sickle-shaped red blood cells (RBCs) block blood vessels. Blood and oxygen cannot get to tissues, causing pain. A sickle cell crisis can also damage your tissues and cause organ failure, such liver or kidney failure.
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