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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Modification of the RNA backbone improves the stability of siRNA without affecting its RNAi efficiency . The selection of siRNA delivery systems depends on the properties of siRNA, the type of target cells, and the delivery routes for in vivo application.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.researchgate.net/topic/siRNA-Delivery
Sep 14, 2018 · I am able to image the intracellular trafficking and uptake of a variety of siRNA delivery vehicles using TEM, but have been unable to localize the point of complex dissociation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · Delivery systems that can improve siRNA stability and cancer cell-specificity need to be developed, nonspecific immune stimulatory effects and involve the minimizing of off-target. The delivery systems must be optimized for specific cancers, as the route of administration may differ depending on the nature of cancer.Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.slideshare.net/axmedaxundov/sirna-delivery
Sep 05, 2015 · Delivering Small interfering RNA or si-RNA molecules in-vivo to treat diseases. Definitions, Approaches, Barriers, Solutions, Delivery systems, and more. With …
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Another lipid-like delivery system is lipidoid nanoparticles, which are comprised of cholesterol and PEG-modified lipids specific for siRNA delivery . To improve SNALP-mediated delivery, Akinc et al. developed a new chemical method for the rapid synthesis of a large library of …Author: Cong-fei Xu, Jun Wang
https://www.biosyn.com/tew/In-vivo-delivery-of-lipophilic-siRNA.aspx
RNA interference (RNAi) is a conserved biological process for specific silencing of gene expression. Small interfering RNAs (siRNAs) are important tools for the control of gene expression, such as post-transcriptional gene silencing in mammals, including humans.However, to function as desired, they need to be taken up by cells or tissues and delivered to selected targets.
https://www.thoughtco.com/what-is-sirna-and-how-is-it-used-375598
Small interfering RNA (siRNA) are small pieces of double-stranded (ds) RNA, usually about 21 nucleotides long, with 3' (pronounced three-prime) overhangs (two nucleotides) at each end that can be used to "interfere" with the translation of proteins by binding to and promoting the degradation of messenger RNA (mRNA) at specific sequences.
https://www.hindawi.com/journals/jdd/2017/6971297/
Over the past 20 years, a diverse group of ligands targeting surface biomarkers or receptors has been identified with several investigated to target siRNA to tumors. Many approaches to developing tumor-homing peptides, RNA and DNA aptamers, and single-chain variable fragment antibodies by using phage display, in vitro evolution, and recombinant antibody methods could not have been imagined by ...Author: Qixin Leng, Martin C. Woodle, A. James Mixson
http://www.invivotransfection.com/
However, delivery to organs, tissues or cells of therapeutic genetic molecule mimics (DNA, RNA, Protein) is a complex problem, requiring passage across several membranes intended to keep external DNA/RNA out of intercellular compartments.
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