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https://www.webmd.com/food-recipes/food-poisoning/what-is-shigella
Shigella is a type of bacteria that can cause severe diarrhea, most often in children. WebMD explains causes, symptoms, and treatment.
https://www.cdc.gov/shigella/index.html
Jan 17, 2018 · Shigellosis is an infectious disease caused by a group of bacteria called Shigella (shih-GEHL-uh). Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Shigellosis usually resolves in 5 to 7 days.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487226/
May 15, 2015 · Introduction of the S. flexneri Type 3 Secretion System into E. coli. Given our interest in developing a nonpathogenic protein delivery strain for therapeutic purposes, our efforts focused on introducing a functional type 3 secretion-based system into DH10β, a laboratory strain of E. coli that, like most Gram-negative bacteria, secretes few, if any, proteins into the extracellular milieu ...Author: Analise Z. Reeves, William E. Spears, Juan Du, Kah Yong Tan, Amy J. Wagers, Cammie F. Lesser
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423471/
Shigella injects a subset of effectors (secreted virulence proteins) via a type III secretion system (T3SS) (protein delivery system) into host cells, allowing the bacterium to invade, multiply within the intestinal epithelium, and subvert cellular and immune functions during bacterial internalization (1, 2).Author: Hiroshi Ashida, Hitomi Mimuro, Chihiro Sasakawa, Chihiro Sasakawa
https://www.cdc.gov/shigella/symptoms.html
Jul 25, 2017 · About 2% 1-4 of people who are infected with the type of Shigella called Shigella flexneri will experience post-infectious arthritis, which causes joint pains, eye irritation, and painful urination. The syndrome only occurs in people who have specific genetic makeup that puts them at risk 1,5-7.It can last for months or years, and can lead to chronic arthritis.
https://pubs.acs.org/doi/pdf/10.1021/acssynbio.5b00002
delivery strain, we first investigated whether this strain ex-presses a functional type 3 secretion system. mT3 E. coli was Figure 1. Components of the bacterial protein delivery system in Escherichia coli. (1) The delivery apparatus encodes the genes required to assemble a functional type 3 secretion system (T3SS) from Shigella flexneri.
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