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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462857/
Jun 05, 2015 · In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination of oil, surfactant, and cosurfactant.Author: Dong Woo Yeom, Ye Seul Song, Sung Rae Kim, Sang Gon Lee, Min Hyung Kang, Sangkil Lee, Young Wook Cho...
https://www.sciencedirect.com/science/article/pii/S0378517316303428
To improve the dissolution and oral bioavailability (BA) of atorvastatin calcium (ATV), we previously introduced an optimized self-microemulsifying drug delivery system (SMEDDS) using Capmul ® MCM (oil), Tween ® 20 (surfactant), and tetraglycol (cosurfactant).Author: Dong Woo Yeom, Ho Yong Son, Jin Han Kim, Sung Rae Kim, Sang Gon Lee, She Hyon Song, Bo Ram Chae, You...
https://www.ncbi.nlm.nih.gov/pubmed/27125455
Jun 15, 2016 · To improve the dissolution and oral bioavailability (BA) of atorvastatin calcium (ATV), we previously introduced an optimized self-microemulsifying drug delivery system (SMEDDS) using Capmul(®) MCM (oil), Tween(®) 20 (surfactant), and tetraglycol (cosurfactant).Author: Dong Woo Yeom, Ho Yong Son, Jin Han Kim, Sung Rae Kim, Sang Gon Lee, She Hyon Song, Bo Ram Chae, You...
https://onlinelibrary.wiley.com/doi/abs/10.1211/jpp.58.9.0004
Self‐microemulsifying drug delivery systems (SMEDDS) containing atorvastatin have been successfully prepared to improve its bioavailability. SMEDDS is a mixture of lipid, surfactant, and cosurfactant, which are emulsified in aqueous medium under gentle digestive motility in the gastrointestinal tract.Author: HaiRong Shen, MingKang Zhong
https://www.dovepress.com/development-and-optimization-of-a-self-microemulsifying-drug-delivery--peer-reviewed-fulltext-article-IJN
Abstract: In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination of oil, surfactant, and cosurfactant.
http://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2016-9-7-12
The objective of the present study was to develop a novel self micro emulsifying drug delivery system of a poorly water soluble drug Atorvastatin calcium trihydrate. The oral delivery of such drugs is frequently associated with implications of low bio availability, high intra and inter subject variability and lack of dose proportionality.Author: Hyma. P, Laharika Reddy, D. S. S. N. Neelima
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528048/
The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with a high drug load of poorly water-soluble atorvastatin for the enhancement of dissolution and oral bioavailability. Solubility of atorvastatin in oil, surfactant, and cosurfactant was determined.
https://www.mdpi.com/1420-3049/25/7/1703/pdf
Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine Mohsin Kazi 1,2,*, Ahmad A. Shahba 2, Saad Alrashoud 1, Majed Alwadei 1, Abdelrahman Y. Sherif 1 and Fars K. Alanazi 1,2 1 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh-11451, Saudi Arabia;
https://paperity.org/p/107649151/development-and-optimization-of-a-self-microemulsifying-drug-delivery-system-for
International Journal of Nanomedicine Development and optimization of a self-microemulsifying drug delivery system for atorvastatin calcium by using d -optimal mixture design Dong Woo Yeom 1 Ye seul song 1 sung rae Kim 1 sang gon lee 1 Min hyung Kang 1 sangkil lee 0 Young Wook choi 1 0 c ollege of Pharmacy, Keimyung University , Daegu, republic of Korea 1 c ollege of Pharmacy, c hung-a ng ...Author: Dong Woo Yeom, Ye Seul Song, Sung Rae Kim, Sang Gon Lee, Min Hyung Kang, Sangkil Lee, Young Wook Cho...
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