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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418443/
We designed a new block copolymer that assembles into submicron-scale particles and provides for covalently tethering proteins to the particle surface for controlled intra-articular protein delivery. This block copolymer self-assembles into 300 nm-diameter particles with a protein-tethering moiety for surface covalent conjugation of IL-1Ra protein.Author: Rachel E. Whitmire, D. Scott Wilson, Ankur Singh, Marc E. Levenston, Niren Murthy, Andrés J. García
https://www.sciencedirect.com/science/article/pii/S0142961212007661
Intra-articular drug delivery is the most direct route for administering drugs and proteins for arthritis and other joint disorders and conditions. Localized delivery can avoid problems such as systemic toxicity, biological degradation, and biodistribution issues, and can also reduce the total amount of drug used in each treatment.Author: Rachel E. Whitmire, D. Scott Wilson, Ankur Singh, Marc E. Levenston, Niren Murthy, Andrés J. García
http://murthylab.berkeley.edu/wp-content/uploads/Whitmare,%20Biomaterials,%202012.pdf
Drug delivery abstract Intra-articular delivery of therapeutics to modulate osteoarthritis (OA) is challenging. Delivery of interleukin-1 receptor antagonist (IL-1Ra), the natural protein inhibitor of IL-1, to modulate IL-1-based inflammation through gene therapy or bolus protein injections has emerged as a promising therapy for OA.
https://www.researchgate.net/publication/229435044_Self-assembling_nanoparticles_for_intra-articular_delivery_of_anti-inflammatory_proteins
Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy.
https://www.sigmaaldrich.com/catalog/papers/22818981
We designed a new block copolymer that assembles into submicron-scale particles and provides for covalently tethering proteins to the particle surface for controlled intra-articular protein delivery. This block copolymer self-assembles into 300 nm-diameter...
https://ui.adsabs.harvard.edu/abs/2012PhDT.......161W/abstract
The primary goal of this work was to synthesize a block copolymer that could self-assemble into injectable, sub-micron-scale particles and would allow an anti-inflammatory protein, IL-1ra, to be tethered to its surface for efficient protein delivery.Author: Rachel Elisabeth Whitmire
https://www.deepdyve.com/lp/elsevier/self-assembling-nanoparticles-for-intra-articular-delivery-of-anti-QhcTnk8Vuy
Oct 01, 2012 · Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins Delivery of interleukin-1 receptor antagonist (IL-1Ra), the natural protein inhibitor of IL-1, to modulate IL-1-based inflammation through gene therapy or bolus protein injections has emerged as a promising therapy for OA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706605/
Nov 26, 2015 · In addition to viral nanoparticles or VLPs, there are many other naturally occurring self-assembling protein nanoparticles that have been identified from a wide variety of sources . For example, almost all living organisms produce ferritin, a protein whose main function is intracellular iron storage.Author: Jacinto López-Sagaseta, Enrico Malito, Rino Rappuoli, Matthew J. Bottomley
https://www.sciencedirect.com/science/article/pii/S200103701530009X
1. Multivalent nanoparticles favor the generation of potent, long-lived immunoprotection in germinal centers. Recombinant nanoparticles loaded with the desired antigen are designed thoroughly to present multiple copies of a pathogen epitope in a highly ordered manner on the surface of a self-assembling nanoparticle.Author: Jacinto López-Sagaseta, Enrico Malito, Rino Rappuoli, Matthew J. Bottomley
https://pubs.acs.org/doi/full/10.1021/acsami.6b16277
The effectiveness of the core/satellite nanoparticles as protein carrier was demonstrated through the intra-articular delivery of interleukin-1 receptor antagonist (IL-1Ra). We showed that IL-1Ra can effectively self-assemble onto the surface of the polymeric nanoparticles and maintained good protein bioactivity by inhibiting IL-1-mediated signaling.Author: Tingting Wang, Yaqin Tang, Xiao He, Ju Yan, Chenhui Wang, Xuli Feng
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