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https://www.ncbi.nlm.nih.gov/pubmed/21224417
Feb 01, 2011 · Scaling rules for diffusive drug delivery in tumor and normal tissues. Baish JW(1), Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK. Author information: (1)Department of Mechanical and Biomedical Engineering, Bucknell University, Lewisburg, PA 17837, USA. [email protected]: James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033252/
Feb 01, 2011 · Scaling rules for diffusive drug delivery in tumor and normal tissues. ... Drug delivery can be improved by reducing the distance to the nearest vessel and by ensuring that blood flow is sufficiently uniform in the vascular network so that each vessel is well-perfused.Author: James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance ...
https://www.pnas.org/content/108/5/1799
Feb 01, 2011 · Scaling rules for diffusive drug delivery in tumor and normal tissues. James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance L. Munn, Rakesh K. Jain. Proceedings of the National Academy of Sciences Feb 2011, 108 (5) 1799-1803; DOI: 10.1073/pnas.1018154108 .Author: James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance ...
https://www.pnas.org/content/pnas/108/5/1799.full.pdf
Scaling rules for diffusive drug delivery in tumor and normal tissues James W. Baisha,1, Triantafyllos Stylianopoulosb, Ryan M. Lanningb, Walid S. Kamounb, Dai Fukumurab, Lance L. Munnb, and Rakesh K. Jainb,1 aDepartments of Mechanical and Biomedical Engineering, Bucknell University, Lewisburg, PA 17837; and bEdwin L. Steele Laboratory for Tumor Biology,Author: James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance ...
https://www.researchgate.net/publication/49745256_Scaling_rules_for_diffusive_drug_delivery_in_tumor_and_normal_tissues
Scaling rules for diffusive drug delivery in tumor and normal tissues Article (PDF Available) in Proceedings of the National Academy of Sciences 108(5):1799-803 · February 2011 with 52 Reads
https://ui.adsabs.harvard.edu/abs/2011PNAS..108.1799B/abstract
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascular geometry-δ max and λ-readily obtained from vascular images, capture these differences and link vascular structure to delivery in both tissue ...
https://www.nature.com/articles/nrc.2017.93
Dec 01, 2017 · This Review by Dewhirst and Secomb describes the current understanding of drug transport to tumour cells and the progress that has been made in …Author: Mark W. Dewhirst, Timothy W. Secomb
https://core.ac.uk/display/8522781
Scaling rules for diffusive drug delivery in tumor and normal tissues By James W. Baish, Triantafyllos Stylianopoulos, Ryan M. Lanning, Walid S. Kamoun, Dai Fukumura, Lance L. Munn and Rakesh K. Jain
https://www.sciencedirect.com/science/article/pii/S0168365914002685
Drug delivery, on the other hand, seeks to package existing drugs so that active drug is primarily exposed in the tumor , , . Through most of the 1960s and 1970s, drug delivery research was closely tied to drug discovery, seeking to combine a therapeutic drug with a cancer-specific targeting vector to theoretically increase affinity for the ...Author: Joseph W. Nichols, You Han Bae
https://www.nature.com/articles/nnano.2012.45
The blood vessels of cancerous tumours are leaky1,2,3 and poorly organized4,5,6,7. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs ...
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