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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775532/
Aug 20, 2019 · Chemotherapy for tumors is partly limited by the poor vasculature in tumors due to drug delivery impairment, especially in necrotic and hypoxic regions. Salmonella is capable of preferentially replicating in these poorly perfused regions.Author: Ze Mi, Zhi-Chao Feng, Cheng Li, Xiao Yang, Meng-Tian Ma, Peng-Fei Rong
https://www.sciencedaily.com/releases/2018/12/181220122606.htm
Dec 20, 2018 · Bacteria-based drug delivery system that outperforms conventional methods. FULL STORY. An interdisciplinary team of three Virginia Tech faculty members affiliated with the Macromolecules Innovation Institute has created a drug delivery system that could radically expand cancer treatment options.
https://www.nature.com/articles/nature18915
Jul 20, 2016 · An ideal drug-delivery system for cancer therapy should deliver the substance selectively to the tumour to minimize harm to healthy tissues, and should release the drug in a controlled manner. In their attempt to develop such a system, Din et al. focused on quorum-sensing circuits,...Author: Shibin Zhou
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845971/
Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium. PLoS ONE 9: e80050. [PMC free article] Ganai, S, Arenas, RB and Forbes, NS (2009). Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice. Br J Cancer 101: 1683–1691.Author: Kwangsoo Kim, Jae Ho Jeong, Daejin Lim, Yeongjin Hong, Hyung Ju Lim, Geun Joong Kim, So Ra Shin, Je ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157733/
Jan 03, 2011 · SALMONELLA TYPHIMURIUM AS A TREATMENT OPTION. Clostridium and Salmonella species have historically been used most successfully as anti-cancer microbes [1,2,14,15,16]. These organisms have been used directly as therapeutics, as well as delivery vehicles for anti-cancer therapeutics.Author: Daniel M. Wall, C.V. Srikanth, Beth A. McCormick
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040766/
Sep 23, 2016 · S. typhimurium genes are easily manipulated; thus diverse attenuated strains of S. typhimurium have been designed and engineered as tumor-targeting therapeutics or drug delivery vehicles that show both an excellent safety profile and therapeutic efficacy in mouse models.Author: Jin Hai Zheng, Jung Joon Min
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105454/
The systemic Salmonella typhimurium infection used here is one in which the infecting bacteria seed primarily in the liver and spleen, and, furthermore, at least 88% of the liver-resident bacteria are localized within macrophages (39).
https://www.webmd.com/food-recipes/food-poisoning/what-is-salmonella
Fertilizer. The most common way to get salmonella is by eating meat or eggs or drinking milk that’s contaminated. But you can also get it by eating fruits or vegetables that have been in contact with manure from animals that have it. Animal poop is often used in fertilizer for fruits and vegetables,...
https://www.fda.gov/food/buy-store-serve-safe-food/what-you-need-know-about-egg-safety
Fresh eggs, even those with clean, uncracked shells, may contain bacteria called Salmonella that can cause foodborne illness, often called “food poisoning.” The U.S. Food and Drug Administration (FDA) estimates that 79,000 cases of foodborne illness and 30 deaths each year are caused by eating eggs...
https://phys.org/news/2018-12-bacteria-based-drug-delivery-outperforms-conventional.html
Dec 20, 2018 · The new system created at Virginia Tech is known as Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS). Researchers have developed a process to chemically attach nanoparticles of anti-cancer drugs onto attenuated bacteria cells,...
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