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https://journals.sagepub.com/doi/pdf/10.1177/0192623307310955
Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations BRIAN G. SHORT From Allergan, Inc., Irvine, California, USA. ABSTRACT Development of new drug candidates and novel delivery techniques for treatment of ocular diseases has recently accelerated. Tre atment of anterior-
https://journals.sagepub.com/doi/full/10.1177/0192623307310955
Jan 01, 2008 · Safety Evaluation of Ocular Drug Delivery Formulations: Case Studies Injectable Therapies Most injectable therapies are used intravitreally, and there is a plethora of literature on the safety and pharmacokinetics of these formulations by this route, mostly conducted in rabbits.Author: Brian G. Short
https://www.researchgate.net/publication/5515546_Safety_Evaluation_of_Ocular_Drug_Delivery_Formulations_Techniques_and_Practical_Considerations
Request PDF Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations Development of new drug candidates and novel delivery techniques for treatment of ...
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/nonclinical-safety-evaluation-reformulated-drug-products-and-products-intended-administration
Nonclinical Safety Evaluation of Reformulated Drug Products and Products Intended for Administration by an Alternate Route October 2015. Download the Final Guidance Document. Final.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
Several liposomal formulations for ocular drug delivery are being exploited, few are in pre-clinical and clinical study stage and few are commercially available. Visudyne ® and Tears again ® are the examples of commercially available liposomal formulations for the treatment of ocular diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/science/article/pii/S1359644618304288
The safety evaluation of ocular long-acting delivery (LAD) technologies is a nascent field. Here, we detail the challenges in assessing the safety of novel LAD technologies, and well as the most common types of toxicity encountered during early toxicity testing.Author: Evan A. Thackaberry, Florence Lorget, Cindy Farman, Vladimir Bantseev
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834906/
Mar 08, 2012 · 2. Ocular Drug Delivery. Current innovation in glaucoma treatment is focused on the improvement of drug delivery methods. The aim is to deliver drugs locally in a controlled manner while mitigating the challenge of poor patient adherence, compliance, and persistence.Author: Nathan Gooch, Sarah A. Molokhia, Russell Condie, Randon Michael Burr, Bonnie Archer, Balamurali K. A...
http://europepmc.org/abstract/MED/18337221
Jan 01, 2008 · Development of new drug candidates and novel delivery techniques for treatment of ocular diseases has recently accelerated. Treatment of anterior-segment diseases has witnessed advances in prodrug formulations and permeability enhancers.Author: Brian G. Short
https://www.sciencedirect.com/topics/medicine-and-dentistry/ocular-drug
If marketed LN formulations (the ultimate goal for ocular drug delivery), are currently missing, the growing literature and patenting activity concerning LNs for ocular delivery indicate their future potentiality, considering their versatility of production and ease of functionalization.
https://www.researchgate.net/publication/312005275_Safety_Evaluation_of_Ocular_Drugs
The safety and effectiveness of systemic and topical medical therapies for ocular disorders are limited due to poor ocular drug uptake, nonspecificity to target tissues, systemic side effects, and ...
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