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https://www.ncbi.nlm.nih.gov/pubmed/24654618
SUMMARY The practice of delivering analgesic drugs into the intrathecal space has evolved over the past several decades from a 'last-ditch' therapy for intractable pain in patients with terminal cancer to a more widely applied strategy for treating patients with chronic nonmalignant pain as well.Author: R Carter W Jones, Tobias Moeller-Bertram, Mark S Wallace
https://www.researchgate.net/publication/261030253_Safety_and_efficacy_of_intrathecal_drug_delivery_for_pain
An IT drug delivery system consists of an intrathecal catheter and a “pump”—a device containing a drug reservoir, pumping mechanism, and often a battery for driving drug delivery.
https://journals.lww.com/anesthesia-analgesia/fulltext/2020/02000/intrathecal_drug_delivery_systems_for_cancer_pain_.6.aspx
The safety and efficacy of intrathecal drug delivery systems (IDDSs) for the treatment of cancer-related pain have been demonstrated in randomized controlled clinical trials (RCTs). Despite positive evidence for this therapy, IDDS remains underutilized to treat cancer pain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892916/
Jul 28, 2014 · Intrathecal drug delivery is an effective pain management option for patients with chronic and cancer pain. The delivery of drugs into the intrathecal space provides superior analgesia with smaller doses of analgesics to minimize side effects while significantly improving quality of life.Author: Gaurav Bhatia, Mary E Lau, Katharine M Koury, Padma Gulur
https://www.clinicalpainadvisor.com/home/topics/chronic-pain/intrathecal-bolus-drug-delivery-safe-for-breakthrough-pain/
Sep 28, 2017 · Intrathecal Bolus Drug Delivery Safe for Breakthrough Pain Drug delivery with an intrathecal bolus is safe for the treatment and management of unpredictable breakthrough pain and may optimize care...
https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=1999&issue=03000&article=00026&type=Fulltext
Whereas epidural opioid analgesia has enjoyed widespread popularity, the intrathecal route is associated with inferior efficacy and safety, primarily because of a higher reported incidence of respiratory depression and somnolence .
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