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https://pubmed.ncbi.nlm.nih.gov/3777589/
Eighty levels drawn from 0 to 16 hours after ingestion were evaluated. To standardize the data, only first levels drawn in patients without prior spontaneous or ipecac-induced vomiting were analyzed (n = 26). Of these 26 levels, eight (31%) were drawn from 0 to two hours after ingestion, eight (31%) from two to four hours, and ten (38%) from four to 16 hours, with correlations of …
https://pubmed.ncbi.nlm.nih.gov/22008309/
Time to rescue was found to be 3.9 and 2.1 hours, respectively, for total hip and knee arthroplasty compared with 0.8 hours for the placebo group. Rescue medication consumption, requests, and actual administration were all significantly lower in the IV acetaminophen group compared with placebo for each dosing interval, except in the 6- to 12-hours interval where a numerical trend …
https://pubmed.ncbi.nlm.nih.gov/30297499/
The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38.0°C) to the rates of patients in whom no antipyretics were administered. No placebo was administered to controls.
https://broomedocs.com/wp-content/uploads/2018/10/Murata-Febrile-seizures.pdf
May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38.0°C) to the rates of patients in whom no antipyretics were administered. No placebo
https://pubmed.ncbi.nlm.nih.gov/7161411/
Plasma concentrations of AAP were determined by high-pressure liquid chromatography for up to 12 hours after the dose. In both the young and the elderly groups, the four oral modes of administration were significantly different with respect to peak plasma concentration (P less than 0.001), time to peak plasma concentration (P less than 0.001), and systemic availability (P less …
https://www.soard.org/article/S1550-7289(14)00357-8/pdf
regression model. IV acetaminophen was the only variable significantly associated with narcotic analgesic demand and requirement in the postoperative 24-hour period and was the only variable included in the final regression model (Table 2). The coefficients of IV acetaminophen in each regression model indicate that the use of IV acetaminophen
https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.1442
Given the sparse and unbalanced sampling scheme, for simplicity, only adduct concentrations obtained within 48 hours of an APAP dose were included in the regression analysis. The base bivariate linear model consisted of an intercept term and a slope term multiplied by the cumulative dose as the explanatory variable for adduct concentrations.
https://jamanetwork.com/journals/jama/fullarticle/2676110
In the meta-regression analysis exploring the effects of potential sources of heterogeneity, such as gestational age, birth weight, and year of publication, a high dose of oral ibuprofen remained the best-ranked treatment for PDA closure (eTables 37-44 and eText 3 …
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