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https://pubs.acs.org/doi/10.1021/bm401906p
In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG for efficient brain-targeted delivery of siRNA.Author: Yikun Gao, Zhan-You Wang, Jinghai Zhang, Youxi Zhang, Hong Huo, Tianyi Wang, Tongying Jiang, Siling ...
https://www.ncbi.nlm.nih.gov/pubmed/24547943
Mar 10, 2014 · In vivo imaging analysis showed significant accumulation of Cy5-siRNA in the isolated brain of mice injected with RVG-peptide-linked complexes. Therefore, the RVG-peptide-linked TMC-PEG developed in this study can be used as a potential carrier for delivery of siRNA to the brain.Author: Yikun Gao, Zhan-You Wang, Jinghai Zhang, Youxi Zhang, Hong Huo, Tianyi Wang, Tongying Jiang, Siling ...
https://www.researchgate.net/publication/260250912_RVG-Peptide-Linked_Trimethylated_Chitosan_for_Delivery_of_siRNA_to_the_Brain
RVG-Peptide-Linked Trimethylated Chitosan for Delivery of siRNA to the Brain. In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG for efficient brain-targeted delivery of siRNA.
https://www.sciencedirect.com/science/article/pii/S0142961212010551
In this study, both RVG (rabies virus glycoprotein) peptide and chitosan-conjugated Pluronic-based nano-carrier was applied as a brain-targeted imaging and protein delivery vehicle. RVG short peptide can bind to acetylcholine receptor in neuronal cells [30] , and it was employed as a targeting ligand to the brain [31] for RMT-based system.Author: Ja-Young Kim, Won Il Choi, Young Ha Kim, Giyoong Tae
https://www.sciencedirect.com/science/article/pii/S0006899320300949
Effective transport of therapeutic nucleic acid to brain has been a challenge for the success of gene therapy for treating brain diseases. In this study, we proposed liposomal nanoparticles modified with brain targeting ligandsfor active brain targeting with enhanced BBB permeation and delivery of genes to brain.Author: Bruna dos Santos Rodrigues, Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh
https://www.researchgate.net/publication/26331169_Preparation_and_characterization_of_chitosanpolyguluronate_nanoparticles_for_siRNA_delivery
In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG for efficient brain-targeted delivery ...
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