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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia.
https://www.sciencedirect.com/science/article/pii/S0014488618306010
Insulin delivery via intracerebroventricular, intranasal, ocular, and intrathecal routes will be discussed in the following sections. 2.2. Intracerebroventricular administration. Intracerebroventicular (ICV) injections take advantage of delivery of insulin directly to the CSF for distribution of insulin …Author: Elizabeth M. Rhea, Therese S. Salameh, William A. Banks
https://care.diabetesjournals.org/content/3/2/219
Mar 01, 1980 · The relative merits of intraperitoneal (i.p.) and subcutaneous (s.c.) insulin delivery compared with intravenous (i.v.) delivery were investigated in seven diabetic patients using a combination of glucosecontrolled closed-loop (Biostator) and portable open-loop (Siemens minipump) insulin infusion systems. With appropriate algorithms for feedback-controlled insulin infusion, it could …Author: Karl Irsigler, Harrald Kritz
https://diabetes.diabetesjournals.org/content/28/12/1069
Dec 01, 1979 · Compared with the i.v. and s.c. routes of insulin delivery, only 50% of the i.p. delivered insulin appeared in the plasma. The onset of the biologic activity of the insulin delivered by the three different routes during the 4½-h observation period was most rapid for the i.v. and least rapid for the s.c. route.Author: Schade Ds, Eaton Rp, Friedman N, Spencer W
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1464-5491.2003.01076.x
The respiratory tree, with a large surface area, offers the greatest potential for the delivery of polypeptide drugs and there is renewed interest in administrating insulin by the intrapulmonary route. Current pulmonary drug delivery systems include a variety of pressurized metered dose inhalers, dry powder inhalers, nebulizers and aqueous mist inhalers.Author: D. R. Owens, B. Zinman, G. Bolli
https://www.ncbi.nlm.nih.gov/pubmed/30500332
These alternative administrative routes can be utilized to increase the amount of CNS insulin and aid in overcoming CNS insulin resistance. This review focuses on the intravenous, intracerebroventricular, intranasal, ocular, and intrathecal routes of administration and compares the impact of insulin delivery.Author: Elizabeth M. Rhea, Therese S. Salameh, William A. Banks
https://www.futurelearn.com/courses/understanding-insulin/0/steps/22476
It can be drawn out of an insulin vial ONLY using an insulin syringe. When injecting insulin, it is important to allow at least 10 seconds before the needle is removed. This helps to ensure that the full insulin dose administered is absorbed. Wet skin at the injection site after the needle is removed could be insulin that has not been absorbed.
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