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https://www.researchgate.net/publication/329681439_Routes_and_formulations_for_delivery_of_antisense_oligonucleotides
Download Citation Routes and formulations for delivery of antisense oligonucleotides Initial efforts in the creation of antisense therapeutics have focused on fundamental questions such as ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459548/
Introduction. Antisense oligonucleotides (AONs) are short chemically modified RNA molecules that can be used to modulate splicing. Splice modulation is currently in development as a potential treatment for multiple rare diseases, including Duchenne muscular dystrophy (DMD). 1,2,3,4 DMD patients lack dystrophin due to frame-shifting or nonsense mutations in the DMD gene, which leads to ...Author: Maaike van Putten, Courtney Young, Sjoerd van den Berg, Amanda Pronk, Margriet Hulsker, Tatyana G Ka...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.researchgate.net/publication/282736442_Liposome-based_formulations_for_the_delivery_of_oligonucleotides
Request PDF Liposome-based formulations for the delivery of oligonucleotides Antisense oligonucleotides are molecules that are able to inhibit gene expression being therefore potentially ...
https://www.sciencedirect.com/science/article/abs/pii/S0022354916324522
Oral Delivery of Antisense Oligonucleotides in Man. ... Treatment of systemic disease with phosphorothioate antisense oligonucleotides (PS ASOs) has been accomplished using local or parenteral routes of administration to date. This report describes, for the first time, the effective oral delivery of a second generation oligonucleotide where ...Author: Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
https://onlinelibrary.wiley.com/doi/full/10.1002/jps.21084
Aug 22, 2007 · Antisense oligonucleotides (ASOs) are synthetic oligonucleotides, usually between 15 and 25 bases in length that are designed to hybridize to mRNA through WatsonâCrick base pairing. Upon binding to the target mRNA, the oligonucleotide inhibits expression of the encoded protein product in a sequence specific manner.Author: Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
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