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https://www.researchgate.net/publication/8148782_Role_of_Metabolism_in_Ocular_Drug_Delivery
Role of Metabolism in Ocular Drug Delivery. ... in the eye their expression levels are low and their functional role in drug metabolism and pharmacokinetics of the eye is unclear ( Nakano et al ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=5&issue=6&spage=507
Keywords:ocular metabolism, cytochrome p-450, drug delivery, detoxification, prodrugs. Abstract: Metabolism is one of the primary routes of drug elimination from the body. This process comprises of mechanisms, such as oxidation and conjugation, which lead to inactivation and / or elimination from hepatic, biliary, pulmonary, renal and ocular ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964012/
Jan 15, 2020 · The application of nanosuspensions in oral, ocular and pulmonary drug delivery systems have been extensively researched during the last few decades. Further, utilization of nanosuspensions in other drug delivery systems such as brain, topical, buccal, nasal and transdermal routes are under extensive investigation.Author: Shery Jacob, Anroop B. Nair, Jigar Shah
https://www.ingentaconnect.com/content/ben/cdm/2004/00000005/00000006/art00003
These enzymes play an important role in ocular homeostasis by preventing entry and / or eliminating xenobiotics from the ocular tissues. Scientists have targeted these enzymes in drug design and delivery through prodrug derivatization. The prodrugs undergo biotransformation to the parent drug by ocular enzymatic degradation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · The most commonly applicable influx transporters for ocular drug delivery are amino acid and peptide transporters. These proteins may have a putative role in ocular drug delivery along with their physiological role of transporting various amino acids and nutrients into ocular tissues.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/B9781907568862500071
With the knowledge of the enzyme content of the ocular tissues, co-drug delivery using enzyme inhibitors or efflux protein inhibitors can be a promising strategy. The Innovative Vision Products company studied the utility of peptidase enzyme inhibitors in a co-drug formulation to modulate transport and metabolism of N -acetylcarnosine prodrugs.Author: Megha Barot, Mitesh Patel, Deep Kwatra, Ashim K. Mitra
https://www.sciencedirect.com/book/9781907568862/ocular-transporters-and-receptors
Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge …
https://www.researchgate.net/publication/5990003_Phase_I_and_Phase_II_Ocular_Metabolic_Activities_and_the_Role_of_Metabolism_in_Ophthalmic_Prodrug_and_Codrug_Design_and_Delivery
Phase I and Phase II Ocular Metabolic Activities and the Role of Metabolism in Ophthalmic Prodrug and Codrug Design and Delivery.pdf Available via license: CC BY 4.0 Content may be subject to ...
http://dmd.aspetjournals.org/content/44/8/1304
Aug 01, 2016 · Although ocular transport and delivery have been well studied, metabolism in the eye is not well documented, even for clinically available medications such as levobunolol, a potent and nonselective β -adrenergic receptor antagonist. Recently, we reported an in vitro methodology that could be used to evaluate ocular metabolism across preclinical species and humans. The current …Author: Upendra A Argikar, Jennifer L Dumouchel, Christine E Dunne, Chitra Saran, Amanda L Cirello, Mithat G...
https://www.mdpi.com/1420-3049/12/3/373/htm
Various review articles have been published to date describing the strategies employed for enhancing ocular drug delivery [2,3,4,5,6] but only a few studies have addressed phase I and phase II ocular metabolic activity and their utility in metabolism-focused, ophthalmic-specific drug design. This specific area is the focus of this review.Author: Abeer M Al-Ghananeem, Peter A Crooks
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