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https://www.sciencedirect.com/science/article/pii/S0022354918301904
In addition, the inclusion complex prevents drug-drug or drug-excipient interactions. 4 CDs are useful in cancer therapy because they increase the loading capacity and encapsulation efficiency of tumor-targeting nanoparticle (NP) delivery systems. 9 Gene delivery uses CDs to assist in the destabilization of biological membranes because CDs bind and remove the cholesterol in the membrane, making the cell …Author: Haley Shelley, R. Jayachandra Babu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750546/
Oct 14, 2005 · The purpose of this review is to discuss and summarize some of the interesting findings and applications of cyclodextrins (CDs) and their derivatives in different areas of drug delivery, particularly in protein and peptide drug delivery and gene delivery.Author: Rajeswari Challa, Alka Ahuja, Javed Ali, R. K. Khar
https://notendur.hi.is/~thorstlo/oral.pdf
Including cyclodextrins in solid dosage forms will increase the In general, drug stabilization associated with cyclodextrin com- formulation bulk and, thus, cyclodextrins can only be included in plexation plays only a very minor role when it comes to drug solid dosage forms of relatively potent drugs.
https://www.researchgate.net/publication/233510282_Role_of_Cyclodextrins_in_Improving_Oral_Drug_Delivery
Role of Cyclodextrins in Improving Oral Drug Delivery. The use of high-throughput screening and similar techniques in drug discovery has put a number of evolutionary pressures on drug candidates such that over time there is a tendency for them to increase in molecular weight, increase in log K(octanol/water) and decrease in water solubility.
https://link.springer.com/article/10.2165%2F00137696-200402040-00006
Aug 20, 2012 · An important tool in this regard is the use of cyclodextrins, especially chemically modified cyclodextrins. These starch derivatives interact via dynamic complex formation and other mechanisms in a way that camouflages undesirable physicochemical properties, including low aqueous solubility, poor dissolution rate and limited drug stability.Author: Thorsteinn Loftsson, Marcus E. Brewster, Már Másson
https://www.mdpi.com/2218-0532/87/4/33
Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers View Full-Text Download PDF Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic.Author: Ádám Haimhoffer, Ágnes Rusznyák, Katalin Réti-Nagy, Gábor Vasvári, Judit Váradi, Miklós Vecsernyés, ...
https://www.ncbi.nlm.nih.gov/pubmed/16296758
In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs, and to increase their bioavailability and stability. Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation.Author: Thorsteinn Loftsson, Pekka Jarho, Már Másson, Tomi Järvinen
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