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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648919/
Feb 02, 2012 · Entry of blood circulating agents into the brain is highly selectively con-trolled by specific transport machineries at the blood brain barrier (BBB), whose excellent barrier restrictiveness make brain drug delivery and targeting very challenging.Author: Yadollah Omidi, Jaleh Barar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. This is a pronounced challenge for the pharmaceutical fraternity.Author: Mayur M. Patel, Bhoomika M. Patel
https://www.nature.com/articles/nrd2368
Aug 01, 2007 · Fenart, L. et al. Inhibition of P-glycoprotein: rapid assessment of its implication in blood–brain barrier integrity and drug transport to the brain by an in vitro model of the blood–brain ...Author: Romeo Cecchelli, Vincent Berezowski, Stefan Lundquist, Maxime Culot, Mila Renftel, Marie-Pierre Deho...
https://www.ncbi.nlm.nih.gov/pubmed/31916480
Jan 09, 2020 · The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome this limitation, the use of nanocarriers for drug delivery across the BBB has recently been exploited.Author: John J.E. Mulvihill, Eoghan M. Cunnane, Aisling M. Ross, Jason T. Duskey, Giovanni Tosi, Andreas M. ...
https://www.brainfacts.org/Brain-Anatomy-and-Function/Anatomy/2014/Blood-Brain-Barrier
Jul 02, 2014 · Developing Drugs that Can Penetrate Blood-Brain Barrier. Repairing leaks in the blood-brain barrier is one hurdle for scientists. Another is determining new ways to create openings in the barrier so that life-saving drugs can access the brain.
https://www.nature.com/articles/s41568-019-0205-x
Oct 10, 2019 · The brain microenvironment can thwart the effectiveness of drugs against primary brain tumours as well as brain metastases. In this Review, we highlight the cellular and molecular components of the...Author: Costas D. Arvanitis, Gino B. Ferraro, Rakesh K. Jain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · Drug transport across the blood–brain barrier. William M Pardridge 1, * ... diffusion plays no role in the transvascular route of drug delivery to the brain. ... 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors. Bioconjug ...Author: William M Pardridge
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