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https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo —however, this section will focus mainly on the development of non-viral materials (Table 1). Of the non-viral RNA delivery vehicles, nanoparticles are perhaps the most studied.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
http://veritasbiollc.com/rna-delivery-technology/
RNA Delivery Technology Delivery of RNAi: A novel approach for delivery of Nucleic Acids to Cells Provides a solution to the rate-limiting step in the delivery of RNA-based drugs (RNAi, miRNA, mRNA).
http://news.mit.edu/2019/rna-vaccine-delivery-0930
Sep 30, 2019 · Delivery system can make RNA vaccines more powerful. Vaccines packaged in novel nanoparticles could offer a new way to fight cancer and infectious diseases.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800065
Aug 21, 2018 · Here, the authors present an overview of RNA‐based therapeutics and recent advances including their delivery systems and clinical applications. In addition, the current challenges of RNA‐based drugs are discussed, followed by perspectives with regard to the development of these promising drug candidates to elicit successful clinical outcomes.Author: Hojeong Shin, Se‐Jin Park, Yeajee Yim, Jungho Kim, Chulwon Choi, Cheolhee Won, Dal‐Hee Min
https://phys.org/news/2018-07-materials-delivery-therapeutic-messenger-rna.html
Jul 16, 2018 · In an advance that could lead to new treatments for a variety of diseases, MIT researchers have devised a new way to deliver messenger RNA (mRNA) into cells.
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · Messenger RNA is highly unstable in extracellular biological fluids due to the presence of nucleases, and an effective delivery vehicle must protect against potential digestion. The proliferation of nanoparticles for mRNA delivery is driven by such a requirement as opposed to the direct conjugates that currently dominate the antisense oligonucleotide (ASO) and siRNA oligonucleotide therapeutic …Author: Matthew G. Stanton
https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Engineered RNA seems stable enough to survive even the hostile acidic environment of the stomach, possibly enabling oral delivery of RNAi therapeutics, say Alnylam. Although the …Author: Bianca Nogrady
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443240/
Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Scientific Reports, 6, 18743. [PMC free article] [Google Scholar] Akinc A, Thomas M, Klibanov AM, & Langer R (2005). Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.Author: Bin Li, Xinfu Zhang, Yizhou Dong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · There is such overlap that miRNA delivery, particularly when double-stranded approximately 21 nt sequences are delivered, that the terminology si(mi)RNA or simply siRNA is recommended by some [ 23 ].Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.nature.com/articles/nature18300
The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen ...Author: Lena M. Kranz, Mustafa Diken, Heinrich Haas, Sebastian Kreiter, Carmen Loquai, Kerstin C. Reuter, Ma...
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