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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pubmed/28379201
Apr 05, 2017 · Therefore, careful design of the delivery systems is essential to fully utilize the potential of this therapeutic solution. This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems. PMCID: PMC5408169 PMID: 28379201. Publication Types: Review ...Author: Katyayani Tatiparti, Samaresh Sau, Sushil Kashaw, Arun Iyer
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open ... safe and effective drug delivery systems. Herein, we review the design criteria for siRNA delivery systems and potential siRNA drug delivery systems for cancer therapy, including chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems ...Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · Springer, A. D. & Dowdy, S. F. GalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics. Nucleic Acid. Ther. 28 , 109–118 (2018). This paper is a review on GalNAc–siRNA ...Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
https://www.researchgate.net/publication/309027511_Biomaterials_in_siRNA_Delivery_A_Comprehensive_Review
Among the above-mentioned siRNA delivery systems, studies on cationic polymers are gaining increasing attention due to their strong capability to condense large …
https://www.nature.com/articles/nrg3978
Aug 18, 2015 · Small interfering RNA (siRNA)-based drugs offer a promising approach to block the synthesis of disease-causing proteins, although their delivery …Author: Anders Wittrup, Anders Wittrup, Judy Lieberman
https://www.researchgate.net/publication/38039955_Peptide_Mediated_siRNA_Delivery
For their delivery, a variety of strategies have been used, most of them based on traditional gene therapy delivery systems. In this review, we present siRNA delivery method strategies and discuss ...
http://www.eurekaselect.com/94942/article
This review focuses on patents describing the siRNA delivery either in naked form or along with a single/multiple delivery vectors. Many inventors have shown promising results for pulmonary utilization of siRNA and more concentration on delivery system may make this genomic approach available to …Author: Nirav I. Khatri, Mohan N. Rathi, Atul A. Kolte, Girish G. Kore, Manisha S. Lalan, Sonia Trehan, Ambi...
https://www.sciencedirect.com/science/article/pii/S0169409X16302046
Recent progress in development of siRNA delivery vehicles for cancer therapy ... and/or inorganic nanoparticles for systemic delivery of siRNA to solid tumors. This review describes the current status of clinical trials related to siRNA-based cancer therapy, as well as the remaining issues that need to be overcome to establish a successful ...Author: Hyun Jin Kim, Ahram Kim, Kanjiro Miyata, Kazunori Kataoka
https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-061010-114133
Unless appropriate experimental measures are taken to control for RNA-induced immunostimulation, genetic manipulation can be confused with immune activation. This review attempts to provide an accessible background in siRNA-relevant immunology and to highlight the ways in which siRNA can be engineered to avoid or provoke an innate immune response.Author: Kathryn A. Whitehead, James E. Dahlman, Robert S. Langer, Daniel G. Anderson
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