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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182074/
Retroviral gene therapy approaches for the treatment of these diseases have to address safety issues. Targeted infection, local delivery, targeted retroviral insertion, insulators, transcriptional targeting, co-transduction with a suicidal gene, and SIN vectors were suggested as possible solutions for the risks of retroviral gene therapy.Author: Youngsuk Yi, Moon Jong Noh, Kwan Hee Lee
https://www.nature.com/articles/3301043
Jan 05, 2000 · Cell type-specific gene delivery will be essential for in vivo gene therapy. Our laboratory has previously developed retroviral vector particles, derived from spleen necrosis virus, SNV, which...Author: A Jiang, R Dornburg
https://www.labome.com/method/Nucleic-Acid-Delivery-Lentiviral-and-Retroviral-Vectors.html
In recent years, retroviral and lentiviral vectors have become increasingly vital tools for the delivery of nucleic acids to many cell types in a variety of experimental systems. In addition to being important in laboratory settings for use in both in tissue culture and animal models, they have also been applied in clinical trials to treat genetic diseases.Author: Erin P O’Keefe
https://www.takarabio.com/learning-centers/gene-function/viral-transduction/recombinant-virus-comparison
However, selecting the best viral gene delivery system for your experimental aim can be challenging. Use the tables below to compare the characteristics of lentivirus, retrovirus, adenovirus, and adeno-associated virus (AAV), and select the best viral transduction system for your experiment.
https://www.sciencedirect.com/science/article/pii/S0734975001000878
Therapeutic gene delivery using retroviral vectors produced by packaging cells (not to scale). Particles released by packaging cells are infectious but replication incompetent. The constitutive release of recombinant retroviral vector particles by such packaging cell lines allows the potential production of large volumes of well-characterised vector stock (Rigg et al., 1996) .Author: Sally McTaggart, Mohamed Al-Rubeai
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
The ability of retrovirus-based gene delivery vectors to carry foreign genetic material was first realized in the early 1980s (El-Aneed, 2004; Escors and Brecpot, 2010). Retroviruses are viruses that integrate with host genome to produce viral proteins (gag, pol, env) that are extracted during gene delivery …Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://gvt-journal.biomedcentral.com/articles/10.1186/1479-0556-2-9
Aug 13, 2004 · The retroviral virion is a spherical particle of about 80–100 nm in diameter. It is enclosed by a lipid bilayer derived from the host cell plasma membrane into which one of the retroviral gene products, the envelope protein, is inserted.Author: Donald S Anson, Donald S Anson, Donald S Anson
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