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https://www.sciencedirect.com/science/article/pii/S1350946216300635
As the mechanisms of retinal diseases are investigated and revealed, new potential drug targets will emerge. The delivery of drugs to retinal targets is challenging and various routes of drug administration have been investigated ().Unfortunately, most of them result in sub-therapeutic drug levels in the retina.Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
The two-day meeting comprised the following nine sessions: (1) eye anatomy and ocular barriers to drug transport, (2) the vitreous humor in drug delivery, (3) intravitreal drug delivery, (4) transscleral drug delivery for retinal diseases, (5) preclinical benchmarks for retinal drug therapy, (6) animal models for evaluating drug delivery ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.sciencedirect.com/science/article/pii/S1359644618305117
The problem of retinal drug delivery. The research on how to counteract the degenerative retinal diseases is extensive . However, in addition to developing compounds that interact with relevant molecular targets, the field must also consider how to deliver new drugs to the retina.Author: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorstei...
https://www.retinalphysician.com/issues/2020/march-2020/the-retinal-drug-delivery-pipeline
Mar 01, 2020 · There are new treatments coming down the pipeline, including the Port Delivery System (PDS; Genentech), sustained-delivery compounds, and gene therapies. In this roundtable discussion, Allen Ho, MD, leads a conversation about pipeline therapies related to retinal drug delivery.Author: Robert L. Avery, MD
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010371/
Jun 18, 2018 · Altogether, a challenging task in retinal drug delivery is to overcome these protective barriers of the eye and deliver the drug with minimal damage to the retinal tissues; a result, there has been a greater interest in research focused on the development of new nanotechnology-based drug delivery systems to facilitate retinal drug administration.Author: Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen
https://www.ondrugdelivery.com/zero-order-sustained-drug-delivery-retina-nanoporous-film-device/
The device itself degrades safely later on, after the drug payload has been completely delivered. Unlike many sustained delivery technologies, these nano-engineered polymer films are functionally tuneable to achieve a zero-order release profile such that drug concentration falls within a narrow range over the course of several months.
https://www.retinalphysician.com/issues/2016/april-2016/suprachoroidal-administration-for-retinal-drug-del
Apr 01, 2016 · Suprachoroidal Administration for Retinal Drug Delivery A promising targeted approach to treat posterior-segment ophthalmic disease SEENU M. HARIPRASAD, MD. R etinal diseases are treated either surgically or pharmacologically. Over the last 10 years, the most common pharmacological method of administering drugs to access the retina or choroid ...
https://cme.healio.com/ophthalmology/20191001/drug-delivery-in-neovascular-retinal-disease/overview?login=1
Drug Delivery in Neovascular Retinal Disease. This activity is supported by an educational grant from Genentech, Inc.
https://www.pnas.org/content/115/13/E2997
Mar 27, 2018 · A major challenge for in vivo drug delivery to the retina is the BRB (18, 38). To facilitate retinal drug delivery, we chose glutathione-targeted PEGylated (GSH-PEG) liposomes, which had previously been shown to be a safe delivery system that favors the transport of cargo across the blood–brain barrier after systemic administration (19, 39).Author: Eleonora Vighi, Dragana Trifunovic, Patricia Veiga-Crespo, Andreas Rentsch, Dorit Hoffmann, Ayse Sah...
https://onlinelibrary.wiley.com/doi/10.1002/wnan.1473
Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high …Author: Rohit Bisht, Abhirup Mandal, Jagdish K. Jaiswal, Ilva D. Rupenthal
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