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https://www.sciencedirect.com/science/article/pii/S0169409X12002037
In most approaches, personalized medicine requires time- and cost-intensive characterization of an individual's genetic background in order to achieve the best-adapted therapy. For this purpose, cell-based drug delivery offers a promising alternative.Author: Markus Wieland, Martin Fussenegger
https://www.researchgate.net/publication/227856414_Reprogrammed_cell_delivery_for_personalized_medicine
Reprogrammed cell delivery for personalized medicine Article · Literature Review in Advanced drug delivery reviews 64(13):1477-87 · June 2012 with 20 Reads How we measure 'reads'
https://www.scientificamerican.com/article/waiting-to-reprogram-your-cells-dont-hold-your-breath/
Mar 15, 2017 · Waiting to Reprogram Your Cells? Don't Hold Your Breath. In a rethink of personalized medicine, researchers turn to banks of donor-derived stem cells
https://www.reprogramcells.com/reprogram-cancer-cells/
A very interesting thesis emerges: a cancer cell is a cell that returns to its archaic state, i.e. when it was a stem cell, and it behaves as such. Its development, however, does no longer occur in the embryonic microenvironment, where all the substances that control and coordinate growth are …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251363/
Jan 30, 2012 · Recently, personalized medicine has mainly involved the systematic use of genetic or other information about an individual patient to select or optimize that patient’s preventative and therapeutic care. Molecular profiling in healthy and cancer patient samples may allow for a greater degree of personalized medicine than is currently available.Author: Mukesh Verma
https://www.kevinmd.com/blog/2011/05/stem-cells-impact-medical-care.html
May 27, 2011 · The induced pluripotent stem cell (or iPSC) also has many of the embryonic stem cells’ characteristics. It is produced by taking a person’s cells such as from the skin of the arm and then stimulating them by inserting a few key genes, using a retrovirus. These genes reprogram the cell to revert to what is similar to an embryonic stem cell.
https://www.reprogramcells.com/
It has been shown that the differentiation factors of the stem cells taken from the embryo of Zebrafish, which has more than 90% of proteins in common with the human ones, are able to differentiate the cell cycle and reprogram cells in a physiological way (without genetic manipulation).
https://www.curetoday.com/community/rick-boulay/2018/07/cancer-redefined-personalized-medicine
But what if there were some way to identify gene mutations causing the cell to behave as a cancer and then, with a medication, undo the effects of the errant gene? This is the basis of personalized medicine. Rather than killing each and every cancer cell (and occasionally the host), what if we could simply persuade them to behave? To act ...
https://www.researchgate.net/publication/308794038_Review_on_Cell_Reprogramming_Methods_and_Applications
Generally it is possible to reprogram personalized ... and direct delivery of reprogramming proteins. ... may present beneficial applications in regenerative medicine. Somatic cell nuclear ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696019/
Unlike viral gene-delivery platforms that result in non-site-specific insertion, ZFNs, ... the promise of mammalian synthetic biology is now being realized in personalized medicine. ... Novel synthetic proteins and genetic circuits can record, perturb, and reprogram cell. functions.Author: Patrick Ho, Yvonne Y Chen
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