Reducible Disulfide Based Non Viral Gene Delivery Systems

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Reducible Disulfide-Based Non-Viral Gene Delivery Systems ...

    https://www.researchgate.net/publication/26883537_Reducible_Disulfide-Based_Non-Viral_Gene_Delivery_Systems
    Reducible Disulfide-Based Non-Viral Gene Delivery Systems. The design and synthesis of safe efficient non-viral vectors for gene delivery has attracted significant attention in recent years due primarily to the severe side-effect profile reported with the use of their viral counterparts.

Reducible Disulfide-Based Non-Viral Gene Delivery Systems ...

    http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-5575&volume=9&issue=10&spage=1242
    Keywords:Disulphide bond, reducible vector, non-viral vector, gene delivery Abstract: The design and synthesis of safe efficient non-viral vectors for gene delivery has attracted significant attention in recent years due primarily to the severe side-effect profile reported with the use of their viral …Author: Defang Ouyang, Neha Shah, Hong Zhang, Sean C. Smith, Harendra S. Parekh

Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.

Recent Advances in the Development of Bio-Reducible ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481959/
    Non-viral gene delivery systems . The development of bio-reducible polymers (PAM-ABP) had showed enhanced gene delivery efficiency with low cytotoxicity. The lack of cell- targeting ability of PAM-ABP, however, is a major obstacle to successful disease specific application.Author: Yong Kiel Sung, Sung Wan Kim

Intracellular organelle-targeted non-viral gene delivery ...

    https://www.sciencedirect.com/science/article/pii/S0168365911000198
    The cytoplasm, nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials. In this review, we explore recently developed non-viral gene carriers based on reducible systems specialized to target the cytoplasm, nucleus and mitochondria.Author: Young-Wook Won, Kwang Suk Lim, Yong-Hee Kim

Reducible Poly(amido ethylenimine)s Designed for Triggered ...

    https://pubs.acs.org/doi/abs/10.1021/bc0602026
    Aug 24, 2006 · Poly(amido ethylenimine) polymers, a new type of peptidomimetic polymer, containing multiple disulfide bonds (SS-PAEIs) designed to degrade after delivery of plasmid DNA (pDNA) into the cell were synthesized and investigated as new carriers for triggered intracellular gene delivery.Author: Lane V. Christensen, Chien-Wen Chang, Won Jong Kim, Sung Wan Kim, Zhiyuan Zhong, Chao Lin, Johan F.J...

Reducible, Dibromomaleimide-linked Polymers for Gene Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255961/
    A class of materials that is highly investigated for non-viral gene transfer is cationic polymers, which condense DNA through electrostatic interactions, protect cargo from early elimination, and can be readily functionalized with molecular targeting agents. 4–7 One of the most effective and commonly used cationic polymers is polyethylenimine (PEI); however, it is non-degradable and has a high density of positive …Author: James Kevin Y Tan, Jennifer L. Choi, Hua Wei, Joan G. Schellinger, Suzie H. Pun

Reducible Poly(amido ethylenimine)-Based Gene Delivery ...

    https://www.researchgate.net/publication/41037766_Reducible_Polyamido_ethylenimine-Based_Gene_Delivery_System_for_Improved_Nucleus_Trafficking_of_Plasmid_DNA
    In a nonviral gene delivery system, localization of a plasmid DNA in the nucleus is a prerequisite for expression of a desired therapeutic protein encoded in the plasmid DNA. In this study, a...

Evaluation of disulfide bond-conjugated LMWSC-g-bPEI as ...

    https://www.sciencedirect.com/science/article/pii/S0144861717310810
    For efficient gene delivery, non-viral vectors should have high cellular uptake, excellent endosomal escape, and the ability to rapidly release the gene into the cytoplasm. Here, we developed a disulfide bond-conjugated bioreducible LMWSC- g -bPEI (LCP) composed of low molecular-weight water soluble chitosan (LMWSC), bPEI, and cystamine (Cys).Author: Gyeong-Won Jeong, Jae-Woon Nah

Dendrimer type bio-reducible polymer for efficient gene ...

    https://www.researchgate.net/publication/224870336_Dendrimer_type_bio-reducible_polymer_for_efficient_gene_delivery
    The development of bio-reducible polymer for gene delivery system has briefly discussed for the efficient cancer gene delivery of viral vectors and non-viral vectors.

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