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https://www.researchgate.net/publication/51071725_Redox-responsive_nanocapsules_for_intracellular_protein_delivery
Request PDF Redox-responsive nanocapsules for intracellular protein delivery Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166028/
Sep 17, 2014 · Introduction. Protein delivery has important applications both in vitro and in vivo.In vitro, delivery of proteins into cells provides a potentially game-changing approach to manipulate signaling pathways, 1 stimulate potent antitumor immune cells, 2 and induce pluripotency for tissue engineering and wound healing. 3 Effective in vivo protein delivery would provide therapeutic replacement of ...
https://www.sciencedirect.com/science/article/pii/S1748013212001405
Highlights We synthesized polymer nanocapsules for delivery of tumor-selective protein. The nanocapsule can be internalized by different tumor cells. The protein cargo is released intracellularly in the cytoplasm. Released complex induced apoptosis and inhibited tumor growth.
https://www.ibridgenetwork.org/#!/profiles/5055150541011/innovations/391/
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http://www.thno.org/v06p2099.htm
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nature Nanotechnology. 2010;5:48-53 5. Zhao M, Biswas A, Hu B, Joo KI, Wang P, Gu Z. et al. Redox-responsive nanocapsules for intracellular protein delivery. Biomaterials. 2011;32:5223-30 6.
https://samueli.ucla.edu/people/yi-tang/
In particular, we are conducting research towards the efficient delivery of various biological molecules to cells and model animals for applications in cancer therapy, imaging, vaccination and reprogramming. These nascent efforts are performed in collaboration with various labs.
https://www.researchgate.net/publication/261702755_Protein_Nanoparticles_for_Intracellular_Delivery_of_Therapeutic_Enzymes
Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic ...
http://scholar.google.com/citations?user=nxhhQxEAAAAJ&hl=en
This "Cited by" count includes citations to the following articles in Scholar. ... Redox-responsive nanocapsules for intracellular protein delivery. M Zhao, A Biswas, B Hu, KI Joo, P Wang, Z Gu, Y Tang ... Endoprotease-mediated intracellular protein delivery using nanocapsules. A Biswas, KI Joo, J Liu, M Zhao, G Fan, P Wang, Z Gu, Y Tang ...
https://onlinelibrary.wiley.com/doi/10.1002/adma.201103458
A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β‐CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles.
http://www.thno.org/v10p4557.htm
Cationic vesicles based on amphiphilic pillar [5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery. Angew Chem Int Ed. 2014;53:13126-30 255. Liu J, Ai X, Zhang H, Zhuo W, Mi P. Polymeric micelles with endosome escape and redox-responsive functions for enhanced intracellular drug delivery. J Biomed Nanotechnol.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201103458/full
The study describes a novel approach to construct a redox responsive controlled release system employing disulfide bonds as coupling linkers to immobilize β‐cyclodextrin grafting polyethylenimine (PEI/β‐CD) molecules onto magnetic nanoparticles for efficient intracellular hydrophobic anticancer drug delivery by endosomal escape.
https://www.chemistry.ucla.edu/directory/tang-yi
My lab has also recently become interested in research at the interface of nanotechnology, biomaterials and drug delivery. In particular, we are conducting research towards the efficient delivery of various biological molecules to cells and model animals for applications in cancer therapy, imaging, vaccination and reprogramming.
https://fan.genetics.ucla.edu/papers/1-s2.0-S0142961212004097-main.pdf
Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor Anuradha Biswasa,c, Ying Liud, Tianfei Liua, Guoping Fand,**, Yi Tanga,b,c,* aDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA b Department of Chemistry and Biochemistry, University of California at Los Angeles ...
http://sites.google.com/site/bionanogu/Publications
Ming Yan+, Juanjuan Du+, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Tatiana Segura, Zheng Liu, Yi Tang*, Yunfeng Lu*, “A Novel Intracellular Protein Delivery Platform Based on Single-Protein Nanocapsules” Nature Nanotechnology, 5(48), 2010. (Highlighted in Science Daily)
http://scholar.google.com/citations?user=dm8DlDMAAAAJ&hl=en
This "Cited by" count includes citations to the following articles in Scholar. ... Redox-responsive nanocapsules for intracellular protein delivery. M Zhao, A Biswas, B Hu, KI Joo, P Wang, Z Gu, Y Tang ... Endoprotease-mediated intracellular protein delivery using nanocapsules. A Biswas, KI Joo, J Liu, M Zhao, G Fan, P Wang, Z Gu, Y Tang ...
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