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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813228/
Postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. Active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. The aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage.Author: Masoumeh Mirteimouri, Fatemeh Tara, Batool Teimouri, Nahid Sakhavar, Afsaneh Vaezi
https://www.aafp.org/afp/2007/0315/p875.html
Oct 15, 2019 · Postpartum hemorrhage, the loss of more than 500 mL of blood after delivery, occurs in up to 18 percent of births and is the most common maternal …Author: Janice M. Anderson, Duncan Etches
https://www.mdedge.com/obgyn/article/110045/obstetrics/stop-using-rectal-misoprostol-treatment-postpartum-hemorrhage-caused
RCTs do not support the use of rectal misoprostol Randomized clinical trials (RCTs) have not demonstrated that misoprostol is superior to oxytocin for the treatment of PPH caused by uterine atony. 2 For example, Blum and colleagues studied 31,055 women who received oxytocin (by IV or IM route) at vaginal delivery and observed that 809 (3% ...
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https://www.drugs.com/pro/cytotec.html
Dec 27, 1986 · the risk of uterine rupture increases with advancing gestational ages and with prior uterine surgery, including cesarean delivery (see also precautions and labor and delivery). cytotec should not be taken by pregnant women to reduce the risk of ulcers induced by nonsteroidal anti-inflammatory drugs (nsaids) (see contraindications, warnings, and ...9.6/10
https://reference.medscape.com/drug/cytotec-misoprostol-341995
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https://journals.lww.com/greenjournal/Fulltext/2004/05000/Oral,_Rectal,_and_Vaginal_Pharmacokinetics_of.8.aspx
Figure 2 shows the mean plasma concentration of misoprostol free acid after oral, rectal, and vaginal administration. In women receiving oral misoprostol, plasma concentration rose quickly, peaked between 7.5 and 30 minutes (mean = 14 minutes) after administration, fell steeply by 60 minutes, and remained low for the remainder of the study period.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633263/
Post-partum hemorrhage (PPH) is a common cause of maternal mortality in developing countries. This trial was conducted to study the effectiveness and safety of rectal misoprostol for PPH.To assess the effectiveness and safety of misoprostol and comparing ...
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