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https://www.tandfonline.com/doi/abs/10.1517/17425247.2011.559223
Apr 09, 2015 · However, the development of clinically suitable, safe and effective drug delivery vehicles is still required. Areas covered: This paper reviews the recent advances of non-viral delivery of small interfering RNA (siRNA) by nanoparticles, including biodegradable nanoparticles, liposomes, polyplex, lipoplex and dendrimers. The characteristics, composition, preparation, applications and advantages of different nanoparticle delivery strategies are also discussed in detail, along with the recent ...Author: Xudong Yuan, Sandy Naguib, Zhiqian Wu
https://www.researchgate.net/publication/50418717_Recent_Advances_of_siRNA_Delivery_by_Nanoparticles
Areas covered: This paper reviews the recent advances of non-viral delivery of small interfering RNA (siRNA) by nanoparticles, including biodegradable nanoparticles, liposomes, polyplex, lipoplex ...
https://www.annualreviews.org/doi/10.1146/annurev-bioeng-071813-105119
Nanoparticulate delivery systems can promote efficient intracellular delivery. Despite showing promise in many preclinical studies and potential in some clinical trials, siRNA has poor delivery efficiency, which continues to demand innovations, from carrier design to formulation, in order to overcome transport barriers.Author: John-Michael Williford, Juan Wu, Yong Ren, Maani M. Archang, Kam W. Leong, Hai-Quan Mao
https://works.bepress.com/zhiqianjames_wu/1/
However, the development of clinically suitable, safe and effective drug delivery vehicles is still required. Areas covered: This paper reviews the recent advances of non-viral delivery of small interfering RNA (siRNA) by nanoparticles, including biodegradable nanoparticles, liposomes, polyplex, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703404/
Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy 1. Introduction. RNA interference (RNAi) is a process by which RNA molecules,... 2. Lipid-Based Nanovectors for Systemic siRNA Delivery. 3. Polymeric Nanoparticles. Polymeric nanoparticles are solid, biodegradable,... 4. ...Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://www.hindawi.com/journals/bmri/2013/782041/
Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://www.sciencedirect.com/science/article/pii/S1359644617304294
Recent advances in siRNA package and release with pH-responsive polymers. (a) pH-sensitive nanomicelles for high-efficiency siRNA delivery in vitro and in vivo. (b) Tumor acidity-sensitive polymeric vector for activated siRNA delivery. (i) Self-assembly of PEG-Dlink m-R9-PCL into nanoparticles to form D m-NP siRNA for siRNA package.Author: Penghui Zhang, Keli An, Xiaoman Duan, Hao Xu, Fei Li, Feng Xu
https://www.sciencedirect.com/science/article/pii/S0065230X17300519
Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Janani Panneerselvam, Akhil Srivastava, Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Thus, in addition to utilizing the delivery of siRNA, Wang et al. utilized NIR irradiation with a wavelength of 808 nm (based on a previous study ) to induce apoptosis in the target cells. A therapy using a combination of phototherapy and siRNA delivery could offer an alternative treatment to eliminate tumors.Author: Michael K. Riley, Wilfred Vermerris
https://www.researchgate.net/publication/262927772_Recent_Advances_in_Nanoparticle-Mediated_siRNA_Delivery
Recent Advances in Nanoparticle-Mediated siRNA Delivery. Inhibiting specific gene expression by short interfering RNA (siRNA) offers a new therapeutic strategy to tackle many diseases, including cancer, metabolic disorders, and viral infections, at the molecular level.
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