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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047505/
Jun 04, 2014 · Pharmaceutical dosage forms that can be sterilized by γ radiation are as follows: Ophthalmic ointments, whose sterile active ingredients and excipients are mixed aseptically... Sterile injectable powders that are unstable in aqueous solutions,... Aerosols, whose …Author: Gürhan Abuhanoğlu, A. Yekta Özer
https://www.drugtimes.org/cytotoxic-drugs/radiotherapy-and-tumortargeted-drug-delivery.html
Oct 16, 2018 · The first concept of using radiation-induced neoantigens as targets for drug delivery was developed and proved several years ago (Hallahan et al. 2001). It was found that blood vessels express a number of cell adhesion molecules and receptors that participate in homeostasis when they are treated with ionizing radiation.
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201700339
Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l ‐cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ‐radiation.Author: Szu Yuan Wu, Hsiao Ying Chou, Chiou Hwa Yuh, Chiou Hwa Yuh, Chiou Hwa Yuh, Shewaye Lakew Mekuria, Yu...
https://clincancerres.aacrjournals.org/content/16/20/4968
Oct 15, 2010 · Radiation-guided delivery of nanoparticles improved both the bioavailability of drug delivery and the efficacy of radiotherapy in mouse models of lung cancer. Further studies are necessary to determine whether improved cancer-specific delivery of radiation-sensitizing chemotherapy translates to reduced side effects and better treatment outcomes in lung cancer patients.Author: Ghazal Hariri, Heping Yan, Hailun Wang, Zhaozhong Han, Dennis E. Hallahan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955851/
Oct 15, 2010 · Radiation-guided delivery of nanoparticles improved both bioavailability of drug delivery and efficacy of radiotherapy in mouse models of lung cancer. Further studies are necessary to determine whether improved cancer-specific delivery of radiation-sensitizing chemotherapy translates to reduced side effects and better treatment outcomes in lung cancer patients.Author: Ghazal Hariri, Heping Yan, Hailun Wang, Zhaozhong Han, Dennis E. Hallahan
https://www.sciencedirect.com/science/article/pii/S0168365919302330
A multi-compartmental pharmacokinetic model (with rate constants estimated from in vitro experiments) predicts that this radiation-controlled drug release technology enables significant improvements in the level and duration of drug availability within the tumor (throughout the typical length of radiation treatment, i.e., > 1 month) over conventional delivery systems (e.g., PEG-PLA micelles with no co …Author: Rahul Misra, Kaustabh Sarkar, Jaewon Lee, Vincenzo J. Pizzuti, Deborah S. Lee, Melanie P. Currie, Sa...
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Furthermore, materials that respond to stimuli such as heat, light, magnetic or electric fields are also being tested to aid target-specific drug delivery and, thus, avoid damage to …Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://www.cancer.gov/nano/cancer-nanotechnology/treatment
These properties enable combination drug delivery, multi-modality treatment and combined therapeutic and diagnostic, known as “theranostic,” action. The physical properties of nanoparticles, such as energy absorption and re-radiation, can also be used to disrupt diseased tissue, as in laser ablation and hyperthermia applications.
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