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https://i-base.info/qa/5255#:~:text=After%20sexual%20exposure%2C%20PEP%20usually%20involves%20taking%20a,window%20to%20do%20this%20%28i.e.%20within%2048%20hours%29.
https://i-base.info/qa/5255
Some guidelines include a two-day window to do this (i.e. within 48 hours). After this, effectiveness is much less likely. Other guidelines allow up to 4 days (i.e. within 72 hours). Sometimes this may be more for psychological benefit. For example, if someone is very stressed or traumatised. No guidelines recommend starting PEP after 72 hours. After finishing PEP you need to wait a 4-6 weeks …
https://www.hiv.gov/hiv-basics/hiv-prevention/using-hiv-medication-to-reduce-risk/post-exposure-prophylaxis
PEP, or post-exposure prophylaxis, is a short course of HIV medicines taken very soon after a possible exposure to HIV to prevent the virus from taking hold in your body. You must start it within 72 hours (3 days) after a possible exposure to HIV, or it won’t work. Every hour counts! PEP should be used only in emergency situations.
https://www.aidsmap.com/news/mar-2020/new-pep-studies-revive-interest-post-exposure-prevention
This in itself is interesting, as it may provide more evidence suggesting that the full IPERGAY regimen (a double dose before exposure and two taken 24 and 48 hours after the double dose) is necessary to offer 100% protection. "The third drug for PEP appears to be necessary: two drugs work for PrEP but not for PEP."
https://www.aidsmap.com/about-hiv/how-effective-post-exposure-prophylaxis-pep
PEP is most effective when it is started soon after exposure to HIV, when doses are not missed and when people complete the 28-day course. The most common cause of HIV infection in people who take PEP is ongoing risk behaviour. Post-exposure prophylaxis (PEP) is a four-week course of medication that may block HIV infection after exposure to the virus.
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