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https://www.prn.org/index.php/transmission/article/post_exposure_prophylaxis_antiretroviral_pharmacokinetics_55#:~:text=Thus%2C%20even%20though%20PEP%20is%20often%20offered%20for,hours%20postexposure%2C%20to%2036%2C%2048%2C%20and%2072%20hours.
https://www.cdc.gov/hiv/clinicians/prevention/pep.html
Exposure to HIV is a medical emergency, because HIV establishes infection very quickly, often within 24 to 36 hours after exposure. Health care providers should evaluate persons rapidly for PEP when care is sought within 72 hours after a potential exposure. pdf icon.
https://www.medicinenet.com/how_effective_is_pep/article.htm
PEP must be started within 72 hours of possible exposure to HIV for it to be effective. It works best if PEP is taken within 24 hours of being exposed to HIV. Medication must be taken as advised, regularly every day for 28 days (4 weeks course). Drug levels must remain high during the month of treatment to help prevent infection. (Irregular medication will lower …
https://www.quora.com/How-effective-is-PEP-after-24-hours
Answer: After 24 hours it can lose its effectiveness. Here is what Igot when I Googled your question: If you believe you have been exposed to HIV, you should seek PEP treatment as quickly as possible. PEP must be taken within 72 hours of exposure or it will have little to no effect in preventing ...
https://www.hiv.gov/hiv-basics/hiv-prevention/using-hiv-medication-to-reduce-risk/post-exposure-prophylaxis
PEP, or post-exposure prophylaxis, is a short course of HIV medicines taken very soon after a possible exposure to HIV to prevent the virus from taking hold in your body. You must start it within 72 hours (3 days) after a possible exposure to HIV, or it won’t work. Every hour counts! PEP should be used only in emergency situations.
https://www.aidsmap.com/news/mar-2020/new-pep-studies-revive-interest-post-exposure-prevention
Secondly, starting PEP promptly, ideally within 12 hours of exposure and certainly within 24 hours, really does make a difference to its efficacy. There is also no new evidence that extending PEP beyond 36 hours helps. Small, discreet vaginal insert also works as PEP
https://www.aidsmap.com/about-hiv/how-effective-post-exposure-prophylaxis-pep
PEP is most effective when it is started soon after exposure to HIV, when doses are not missed and when people complete the 28-day course. The most common cause of HIV infection in people who take PEP is ongoing risk behaviour. Post-exposure prophylaxis (PEP) is a four-week course of medication that may block HIV infection after exposure to the virus.
https://www.cdc.gov/hiv/basics/pep.html
PEP (post-exposure prophylaxis) means taking medicine to prevent HIV after a possible exposure. PEP should be used only in emergency situations and must be started within 72 hours after a recent possible exposure to HIV.
https://www.ncbi.nlm.nih.gov/books/NBK562734/
Post-exposure prophylaxis (PEP) has been established to effectively prevent HIV infection in an exposed individual when initiated within 2 hours (ideal) and no later than 72 hours after an exposure. Rapid and effective response to a reported HIV exposure are key to the successful prevention of HIV infection.
https://www.reddit.com/r/STD/comments/3oo28u/what_is_the_level_of_effectiveness_of_hiv_pep_if/
For example, taking PEP for only 10 days after 24 hours of exposure still has a seroconversion of 50% of the monkeys. You can see that the only choice is 28 days of treatment at 24 hours after exposure. When used, PEP should be initiated promptly. Animal research suggests that PEP may be ineffective if started later than 24 to 36 hours after exposure.
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