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http://www.adgosun.com/COAS/A50.pdf#:~:text=A%20freshly%20prepared%20solution%20of%20paclitaxel%20should%20be,remaining%20dose%20fraction.%20Medical%20personnel%20should%20be%20available.
https://pubmed.ncbi.nlm.nih.gov/10550134/
Conclusion: When administered as a continuous 24-hour infusion, high-dose paclitaxel results in a higher tumor response rate than when administered as a 3-hour infusion but does not significantly improve event-free survival or survival. Paclitaxel as a 24-hour infusion results in increased hematologic toxicity and decreased neurosensory toxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164940/
Paclitaxel is derived from Yews (a type of tree), and can be used to treat for several cancers such as lung, womb, ovary and breast. It was initially given by a long infusion (injection) over 24 hours, with premedication to avoid any allergic reactions. It was also thought this method would be more active against tumours.
https://www.pdr.net/drug-summary/Paclitaxel-paclitaxel-1299
Paclitaxel 135 mg/m2 intravenously over 24 hours on day 1 followed by cisplatin 100 mg/m2 intraperitoneally on day 2 and paclitaxel 60 mg/m2 intraperitoneally on day 8. Administer every 3 weeks for 6 cycles. Extended overall survival and progression-free survival in a phase III trial compared to cisplatin IV/paclitaxel IV.
https://journals.sagepub.com/doi/pdf/10.1177/107327489500200112
tial doses of paclitaxel 125 mg/m 2 over 24 hours (day 1) followed by doxorubicin 60 mg/m 2 over 48 hours (days 2 and 3) had to be reduced paclitaxel 125 mg/m 2 and doxorubicin 48 mg/m 2 as the maximum tolerated dose (MTD) since four of the 1 O patients experienced dose-limiting mucositis. Unexpected severe mucosi
https://pubmed.ncbi.nlm.nih.gov/17072270/
Paclitaxel is generally administered at doses of 175-225 mg/m2 over 3 hours or 135-175 mg/m2 over 24 hours, every 3 weeks. The purpose of this study was to simplify administration and render it suitable and practical in the outpatient setting.
https://www.pfizermedicalinformation.com/en-us/paclitaxel/dosage-admin
Paclitaxel administered intravenously over 24 hours at a dose of 135 mg/m 2 followed by cisplatin at a dose of 75 mg/m 2. 2) In patients previously treated with chemotherapy for carcinoma of the ovary, paclitaxel has been used at several doses and schedules; however, the optimal regimen is not yet clear.
https://www.drugs.com/dosage/paclitaxel.html
175 mg/m2 IV over 3 hours followed by cisplatin 75 mg/m2 IV every 3 weeks OR 135 mg/m2 IV over 24 hours followed by cisplatin 75 mg/m2 IV every 3 weeks For patients previously treated for cancer of the ovary (NOTE: This drug has been used at several doses and schedules; however, the optimal regimen is not yet clear):
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