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https://wrds-www.wharton.upenn.edu/pages/about/data-vendors/pacap/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823792/
These data suggest that the dysfunctions of entrainment and masking were caused by the loss of PACAP, not by the loss of light input itself. Moreover, PACAP-deficient mice express an unusually early onset of activities, from approximately four hours before the dark period, without influencing the phase of the endogenous circadian clock.
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.14453
24 hours at 37°C with different gradient concentrations of PACAP (100µmol/L, 10 µmol/L, 1 µmol/L, 100 nmol/L, 10 nmol/L or 1 nmol/L). For VPAC2, VPAC1 and PAC1 receptor blocking experi‐ ments, the selective inhibitors PG99‐465, PG97‐269 and MMAX.D.4 were used. L02 cells were pre‐incubated for 24 hours at 37°C with
https://pubmed.ncbi.nlm.nih.gov/32877227/
Bronchomotor tone is regulated by contraction and relaxation of airway smooth muscle (ASM). A weakened ASM relaxation might be a cause of airway hyperresponsiveness (AHR), a characteristic feature of bronchial asthma. Pituitary adenylyl cyclase-activating polypeptide (PACAP) is …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063673/
Animals. PACAP-EGFP transgenic mice, Tg(Adcyap1-EGFP)FB22Gsat/Mmucd (RRID:IMSR_MMRRC:012011) were generated using the bacterial artificial chromosome (BAC; RP24-358O1) by the Gene Expression Nervous System Atlas (GENSAT) project (Gong et al., 2003; 2010) and obtained from the Mutant Mouse Resource & Research Centers.This BAC contained the 6.5 kb murine …
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072607
Cell Culture. 3T3-L1 cells, were kindly provided by Dr I. Pirson , and grown in DMEM supplemented with 10% calf serum, 100 U/ml penicillin and 100 mg/ml streptomycin, and in 8% CO 2 /humidified atmosphere at 37°C. Adipocyte differentiation was induced 2 days post-confluence by incubating cells for 60 h in DMEM supplemented with 10% fetal bovine serum and containing 500 µM …
https://www.bachem.com/knowledge-center/white-papers/vip-pacap-peptides/
Analysis showed that PACAP-38 is the predominant form, but the PACAP-38/ PACAP-27 ratio varies between different tissues especially in the central nervous system, adrenal and testis. Fig. 2. Schematic illustration of the general organization of human prepro-VIP, and the location of mature PHM and VIP sequences.
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15700
PACAP-responsive receptors displayed agonist-dependent antagonism where PACAP-38 was less effectively antagonised compared to PACAP-27 and VIP. Conclusions and Implications. The distinct pharmacological profile displayed by the PAC 1s receptor suggests that it can act as a dual receptor for VIP and PACAP. Furthermore, the effectiveness of ...
https://www.hindawi.com/journals/np/2021/2522454/
The present research investigates the molecular mechanism of neurite outgrowth (protrusion elongation) under pituitary adenylate cyclase-activating polypeptide (PACAP) 38 treatments using a rat adrenal-derived pheochromocytoma cell line—PC12. This study specifically looks into the regulation of PACAP38-induced collapsing response mediator protein 2 (CRMP2) previously identified in a mouse ...
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