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https://diabetes.diabetesjournals.org/content/54/6/1649
Jun 01, 2005 · Another clinically relevant aspect of pulsatile insulin delivery that has been proposed is the possibility that pulsatile insulin delivery may avoid downregulation of hepatocyte insulin receptors compared with a comparable constant delivery of insulin . Indeed, in vitro studies have affirmed this notion . The minute-to-minute responsiveness of ...Author: Juris J. Meier, Johannes D. Veldhuis, Peter C. Butler
https://www.ncbi.nlm.nih.gov/pubmed/22688333
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Matveyenko AV(1), Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli …Author: Aleksey V. Matveyenko, David Liuwantara, Tatyana Gurlo, David Kirakossian, Chiara Dalla Man, Claudio...
https://clinicaltrials.gov/ct2/show/NCT00228891
Anecdotal reports have indicated improvement with pulsatile IV insulin in patients otherwise resistant to all conventional therapies. Significant complications produce painful peripheral dysesthesias, loss of sensation and gastroparesis. This study is designed to test the effectiveness of pulsatile insulin delivery on diabetic neuropathy.
https://www.diabetesselfmanagement.com/diabetes-resources/definitions/pulsatile-intravenous-insulin-therapy-pivit/
Apr 18, 2014 · A treatment for difficult-to-treat cases of diabetes, involving weekly six-hour sessions in which a special pump delivers insulin in programmed pulses. This treatment, which more closely mimics insulin delivery from the pancreas than traditional subcutaneous injections or conventional insulin pumps do, can help improve blood glucose control and lower the risk of diabetic complications.
https://diabetes.diabetesjournals.org/content/61/9/2269
Sep 01, 2012 · Insulin is secreted as discrete insulin secretory bursts at ∼5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vein is important for ...Author: Aleksey V. Matveyenko, David Liuwantara, Tatyana Gurlo, David Kirakossian, Chiara Dalla Man, Claudio...
https://www.ncbi.nlm.nih.gov/pubmed/6134649
Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Matthews DR, Naylor BA, Jones RG, Ward GM, Turner RC. The relative hypoglycemic effects of pulsatile versus steadily infused insulin have been examined in six normal subjects in whom pancreatic insulin output was suppressed by somatostatin-14.Author: D R Matthews, B A Naylor, R G Jones, G M Ward, R C Turner
https://www.nature.com/articles/s41598-019-41430-8
Mar 21, 2019 · We propose a wirelessly controlled implantable system for on-demand and pulsatile insulin delivery with a more convenient and safer strategy than currently available strategies. The system is …Author: Seung Ho Lee, Joong Woo Ahn, Yong Chan Cho, Se Na Kim, Cheol Lee, Gi Won Ku, Young Bin Choy, Hee Cha...
https://clinicaltrials.gov/ct2/show/NCT00228865
Sep 29, 2005 · Clinical Effects of Pulsatile Insulin Delivery on Cognitive Function- Phase 1 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
https://academic.oup.com/jcem/article-abstract/66/6/1220/2651733
Jun 01, 1988 · In the normal men, insulin administration resulted in a significant decline of basal plasma glucagon and C-peptide levels and in a clear-cut decrease in the arginine-induced glucagon response. These effects of insulin were significantly more marked when insulin was delivered in a pulsatile rather than a continuous manner.Author: G. Paolisso, S. Sgambato, R. Torella, M. Varricchio, André Scheen, F. D'Onofrio, Pierre Lefebvre
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