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https://www.sciencedirect.com/science/article/pii/0169409X93900283
PULSATILE DRUG DELIVERY SYSTEMS USING HYDROGELS 87 system is called an 'intelligent DDS' [1] (Fig. 1), which is distinguished from the conventional DDS. Intelligent DDS have been developed to deliver drug effectively to the targeting site (targeted, site-specific delivery) and release drug when drug is required (temporal control, self-regulating drug delivery).Author: Ryo Yoshida, Kiyotaka Sakai, Teruo Okano, Yasuhisa Sakurai
https://www.sciencedirect.com/science/article/abs/pii/0169409X93900283
Intelligent drug delivery systems (DDS) are one expected result, demonstrating an ability to sense external environmental changes, judge the degree of external signal, and release appropriate amounts of drug. Intelligent DDS may be achieved using stimuli-responsive polymeric hydrogels which alter their structure and physical properties in response to external stimuli. Pulsatile drug release has the advantages of avoiding drug …Author: Ryo Yoshida, Kiyotaka Sakai, Teruo Okano, Yasuhisa Sakurai
https://www.sciencedirect.com/science/article/pii/S0169409X01002435
In this article several types of drug delivery systems using hydrogels are discussed that showed pulsed and/or pulsatile drug delivery characteristics. As is frequently found in the living body, many vital functions are regulated by pulsed or transient release of …Author: Akihiko Kikuchi, Teruo Okano
https://www.sciencedirect.com/science/article/abs/pii/S0169409X01002435
Jan 17, 2002 · Thermal stimuli-regulated pulsed drug release is established through the design of drug delivery devices, hydrogels, and micelles. Development of modified alginate gel beads with pulsed drug delivery characteristic is also described in this article.Author: Akihiko Kikuchi, Teruo Okano
https://www.ncbi.nlm.nih.gov/pubmed/11755706
Jan 17, 2002 · In this article several types of drug delivery systems using hydrogels are discussed that showed pulsed and/or pulsatile drug delivery characteristics. As is frequently found in the living body, many vital functions are regulated by pulsed or transient release of bioactive substances at a specific site and time.Author: Akihiko Kikuchi, Teruo Okano
https://www.researchgate.net/publication/11601417_Pulsatile_drug_release_control_using_hydrogels
Pulsatile drug delivery systems can be classified into time-controlled devices in which the drug is released after a well-defined time period, or site-specific systems in which the drug is ...
https://www.ijpsonline.com/articles/pulsatile-drug-delivery-systems-an-approach-for-controlled-drug-delivery.pdf
Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery …Author: Shweta Arora, J Ali, Alka Ahuja, Sanjula Baboota, J Qureshi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548250/
Jul 01, 2011 · Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than conventional dosages and increased patient compliance.Author: Deepika Jain, Richa Raturi, Vikas Jain, Praveen Bansal, Ranjit Singh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898614/
The clinical use of drug delivery systems is appreciable 7, with a global market of over $150 US billion in 2013. Hydrogels are a particularly appealing type of drug delivery system, and have been used in many branches of medicine, including cardiology, oncology, immunology, wound healing, and pain management.Author: Jianyu Li, David J. Mooney
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