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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649783/
Conventional drug delivery system of valsartan is inappropriate for the delivery of drug, as they cannot be administered just before the symptoms are worsened. Bedtime dosing of conventional drug dosage of valsartan will not provide a sufficient therapeutic plasma drug concentration at the early hours of morning.
https://www.researchgate.net/publication/326535280_Formulation_and_Evaluation_of_Valsartan_Pulsincap_Drug_Delivery_System_for_Treatment_of_Hypertension
Formulation and Evaluation of Valsartan Pulsincap Drug Delivery System for Treatment of Hypertension ... The aim of the present investigation is to develop a pulsatile drug delivery system basedon ...
https://www.researchgate.net/publication/263169702_Formulation_And_Evaluation_Of_Valsartan_Pulsatile_Drug_Delivery_Systems
Aim: Preparation and evaluation of oral pulsatile drug delivery (PDD) systems to deliver valsartan at the early morning meeting the expected hypertension surge according to the circadian rhythm of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465146/
A pulsatile drug delivery system is characterized by a lag time that is an interval of no drug release followed by rapid drug release. The purpose of this work was to develop hollow calcium alginate beads for floating pulsatile release of valsartan intended for chronopharmacotherapy.
https://www.ijpsonline.com/articles/design-of-chronomodulated-drug-delivery-system-of-valsartan-in-vitro-characterization.pdf
Sokar, et al.: Valsartan Time‑Clock Pulsatile System The aim of the present study was to design and evaluate a chronomodulated time‑clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with
https://www.sciencedirect.com/science/article/pii/S0168365909000923
However, no effort has been made to develop a system for ARBs, which delivers the drug at a specified time and shows maximum effect in the early morning . Hence we made an attempt to formulate a pulsatile capsule-based drug delivery system for delayed delivery of valsartan . Assembly of the pulsed-release capsule device consisted of: i ...Author: Usha Yogendra Nayak, Gopal Venktesh Shavi, Yogendra Nayak, Ranjith Kumar Averinen, Srinivas Mutalik,...
http://ijpar.com/sites/default/files/articles/IJPAR_14_930%2041-47.pdf
evaluation of Valsartan pulsincap for pulsatile drug delivery system . Valsartan pulsincap will be prepared to release the drug after predetermined lag period, to meet the therapeutic requirement of the body. METHODOLOGY PREPARATION OF THE STANDARD CALIBRATION CURVES OF VALSARTAN Standard calibration linearity curve of
http://ajptonline.com/HTMLPaper.aspx?Journal=Asian%20Journal%20of%20Pharmacy%20and%20Technology;PID=2018-8-2-1
The aim of the present study was to develop and evaluate pulsatile drug delivery system of Valsartan for the treatment of hypertension. It is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist that is selective ...Author: Mangesh A. Bhutkar, Somnath D. Bhinge
https://ihelptostudy.com/pulsatile-drug-delivery-system-thesis-proposal.html
Within the time controlled systems the drug release is controlled through the delivery system, in stimuli caused pulsatile system the discharge is controlled by different stimuli for example pH, enzymes contained in the digestive tract or even the delivery system and exterior stimuli like magnetism, ultrasound, electrical effect or irradiation.
https://www.sciencedirect.com/science/article/pii/S1818087613000342
Pulsatile core-in-cup valsartan tablet ... made an attempt to formulate a pulsatile capsule-based drug delivery system for delayed delivery of Val. The objective of the present study was the design and evaluation of promising single pulse and floating double pulse valsartan pulsatile core-in-cup tablets as to optimize the drug release after a ...Author: M.S. Sokar, A.S. Hanafy, A.H. El-Kamel, S.S. El-Gamal
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