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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925008/
Pulmonary Delivery as a Route for Insulin Administration. Since the discovery of insulin over 80 years ago, investigators have sought to develop a pulmonary route of insulin delivery. The pulmonary route of administration offers several advantages. First, the lung has a large surface area for drug absorption, ranging from 100 to 140 m 2.Author: Priscilla A. Hollander
https://www.medscape.org/viewarticle/458389
Oct 26, 2019 · Pulmonary Complications in Diabetes. At a symposium on pulmonary insulin delivery, Connie C.W. Hsia, MD, University of Texas Southwestern Medical Center, Dallas, discussed the pulmonary complications of diabetes. Dr. Hsia pointed out that the disease is associated with increased risk of pneumonia and aspiration, that autonomic neuropathy is associated with disordered breathing …
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary drug delivery is getting more and more magnitude. This is on account of the specific physiological environment of the lung as an absorption and treatment organ. The development of inhalable insulin can be perceived as a milestone in pulmonary drug delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
In a study by Garcia-Contreras et al. reported systemic delivery of insulin administered by the pulmonary route. The insulin formulations were administered by intratracheal instillation, spray instillation, and subcutaneous route.
https://care.diabetesjournals.org/content/27/1/239
Jan 01, 2004 · OBJECTIVE —To comprehensively review the progress to date on the development of alternative routes for insulin delivery. RESEARCH DESIGN AND METHODS —Study data were collected through a Medline review. RESULTS —Proof of principle has been established for many routes of administration including dermal, nasal, oral, buccal, and pulmonary insulin delivery. CONCLUSIONS …Author: William T. Cefalu
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
ABOUT AUTHORS: Dr. N.V. Satheesh Madhav, Girish Dwivedi* Dehradun Institute of Technology, Faculty of Pharmacy Village Makkawala, Mussoorie Diversion Road, Dehradun-248009 *[email protected] ABSTRACT Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for site
https://drug-dev.com/pulmonary-delivery-pulmonary-delivery-of-insulin-to-treat-diabetes-a-debacle/
T.R. Shantha, MD, PhD, FACA, says the market for new anti-diabetic therapeutic agents and their painless delivery is enormous and is sure drug companies and research scientists are in a race to develop a safer method other than the pulmonary and oral routes to deliver insulin.
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