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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842434/
INTRODUCTION. The effects of antenatal corticosteroids on mortality and pulmonary outcomes at the lowest gestations show mixed results, in part due to the small sample size of randomized controlled trials. 1,2 Although antenatal corticosteroids are given primarily to induce pulmonary maturity, induce surfactant release, and decrease respiratory distress syndrome, randomized controlled trials ...Author: Colm P Travers, Waldemar A Carlo, Waldemar A Carlo, Scott A Mcdonald, Abhik Das, Edward F Bell, Nama...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
REFERENCE ID: PHARMATUTOR-ART-1700 INTRODUCTION The delivery of the drug through the respiratory tract is called pulmonary drug delivery. In case of brochodialating drugs, this is advantageous as drug will deliver directly to region where its action is required so that the drug effect will be faster and low dose of drug can be administered through this delivery system and so the side effects ...
https://www.sciencedirect.com/science/article/pii/S0378517313003566
1. Introduction. Sterility is a requisite for ocular formulations including suspensions (EDQM., 2011a) and it has recently become mandatory also for many inhalatory formulations such as nasal liquids and single-dose products for nebulization ().It can be obtained through a sterilization process that can be defined as a procedure affording at least a 6 order of magnitude reduction of the ...Author: Franca Zani, Cristina Veneziani, Elena Bazzoni, Loretta Maggi, Giovanni Caponetti, Ruggero Bettini
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884297/
Apr 18, 2002 · Pulmonary delivery devices. The lung has served as a route of drug administration for thousands of years. The origin of inhaled therapies can be traced back 4000 years ago to India, where people smoked the leaves of the Atropa belladonna plant to suppress cough. In the 19th and early 20th centuries, asthmatics smoked asthma cigarettes that contained stramonium powder mixed with …Author: N. R. Labiris, M. B. Dolovich
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Advantages of pulmonary drug delivery together with the outstanding attributes of nanoscaled systems, such as (1) reduced size and increased surface to volume ratio, (2) high drug-loading efficiency, and (3) efficient absorbance to the lung epithelium and avoidance of pulmonary clearance make inhaled nanoparticles an ideal drug delivery approach.
http://www.pharmtech.com/pulmonary-drug-delivery-particle-engineering-inhaled-therapeutics
Feb 02, 2014 · Pulmonary drug delivery must, therefore, overcome these barriers. The epithelium of the respiratory system varies in thickness and corresponding permeability from the comparatively thick trachea to the more permeable alveoli. Hydrophobic molecules can be absorbed through the transcellular pathway of the lipid bilayer around cells.
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews the issues specific to developing drugs designed for pulmonary delivery and considers how—with the right knowledge and expertise—these challenges …
https://erj.ersjournals.com/content/37/6/1308
Jun 01, 2011 · A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was facilitated by the European Respiratory Society (ERS) and the International Society for Aerosols in Medicine (ISAM), in order to draw up a consensus statement with clear, up-to-date recommendations that enable the pulmonary physician to choose the type of aerosol delivery device that is most suitable ...Author: B.L. Laube, H.M. Janssens, F.H.C. De Jongh, Sunalene Devadason, R. Dhand, P. Diot, M.L. Everard, I. ...
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