Pulmonary Delivery Antibodies

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Pulmonary monoclonal antibody delivery via a portable ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393410/
    The delivery of antibodies via inhalation, particularly for the treatment of lung cancer, is thus expected to enhance the efficacy of this protein therapeutic by increasing the local concentration where they are needed. ... For local delivery, pulmonary delivery can potentially provide a targeted approach for delivering mAbs, particularly for ...Author: Christina Cortez-Jugo, Christina Cortez-Jugo, Aisha Qi, Anushi Rajapaksa, James R. Friend, Leslie Y....

Inhaled protein/peptide-based therapies for respiratory ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839019/
    Apr 20, 2016 · Unlike intravenous administration, pulmonary delivery of omalizumab failed to attenuate the response to inhaled allergens in asthmatic subjects [15, 17]. The observed lack of efficacy in the aerosolization trial was likely a failure of the pulmonary route to deliver sufficient systemic omalizumab to neutralize free systemic IgE . Another ...Author: Robert C. Fellner, Shawn T. Terryah, Robert Tarran

Long-Term Antibody and Immune Memory Response Induced by ...

    https://cvi.asm.org/content/19/1/79
    Jan 01, 2012 · Pulmonary delivery of an influenza Iscomatrix adjuvant vaccine induces a strong systemic and mucosal antibody response. Since an influenza vaccine needs to induce immunological memory that lasts at least 1 year for utility in humans, we examined the longevity of the immune response induced by such a pulmonary vaccination, with and without antigen challenge. Sheep were vaccinated in the deep ...Author: Ana Vujanic, Kenneth John Snibson, Janet Lye-Keng Wee, Stirling J Edwards, Martin J Pearse, Jean-Pie...

Pulmonary Delivery of Insulin - Medscape

    https://www.medscape.org/viewarticle/458389
    Oct 26, 2019 · Pulmonary Complications in Diabetes. At a symposium on pulmonary insulin delivery, Connie C.W. Hsia, MD, University of Texas Southwestern Medical Center, Dallas, discussed the pulmonary complications of diabetes. Dr. Hsia pointed out that the disease is associated with increased risk of pneumonia and aspiration, that autonomic neuropathy is associated with disordered breathing …

Pulmonary monoclonal antibody delivery via a portable ...

    http://users.monash.edu/~lyeo/Dr_Leslie_Yeo/Publications_files/1.4917181.pdf
    device appears to constitute an ideal candidate for the pulmonary delivery of clinically signifi-cant large macromolecules, as we will show in this work. Therapeutic monoclonal antibodies (mAbs) are particularly attractive biomolecules to deliver via the pulmonary route.37,38 Many mAbs have already been approved to treat a wide range of

Pulmonary delivery of triptolide-loaded liposomes ...

    https://www.nature.com/articles/s41598-017-00957-4
    Apr 20, 2017 · Pulmonary delivery of anti-cancer drugs could provide a better retention of active ingredients in the lung and minimize adverse effects on healthy …Author: Congcong Lin, Blenda Chi Kwan Wong, Hubiao Chen, Zhaoxiang Bian, Ge Zhang, Xue Zhang, Muhammad Kashi...

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